cas 6317-97-1, 4,6-Dihydroxy-5-nitropyridine-3-carboxylic acid ethyl ester | Articles data ｜lookchem

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6317-97-1

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Discovery and SAR study of 2-(1-propylpiperidin-4-yl)-3H-imidazo[4,5-c]pyridine-7-carboxamide: A potent inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1) for the treatment of cancer
A series of imidazo[4,5-c]pyridine-7-carboxamide derivatives as poly(ADP-ribose) polymerase (PARP) inhibitors have been developed. All target compounds were evaluated for their PARP-1 inhibitory activity and some were further assessed for cellular potency
Zhu, Qihua,Wang, Xueyan,Hu, Yan,He, Xiaorong,Gong, Guoqing,Xu, Yungen
p. 6551 - 6559
(2015/10/19)

Inhibitors of HIV-1 reverse transcriptase
The present invention provides compounds for treating or preventing an HIV infection, or treating AIDS or ARC comprising administering a compound according to Formulae I and II wherein Q, R1, R2, and R3 are defined as described herein.
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Page/Page column 31

(2010/04/23)

NEW MACROLIDES AND THEIR USE
The invention relates to macrolide compounds of formula (I),the use of said compounds as medicaments, in particular for the treatment or prevention of inflammatory and allergic diseases, pharmaceutical compositions containing said compounds and to process
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Page/Page column 79

(2009/10/21)

NEW MACROLIDES USEFUL AGAINST INFLAMMATORY AND ALLERGIC DISSEASES
Macrolide compounds of formula I: with PDF4 inhibiting activity are described, wherein R1 is a residue -Y-X-Q; Y is S, SO or SO2; X is a bond or a linear group consisting of hydrogen atoms and with up to 9 atoms selected from C, N, O and/or S,
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Page/Page column 51

(2008/06/13)

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Chemical Properties

Melting Point: 243-246oC
Boiling Point: 346.9oC at 760 mmHg
Flash Point:163.6oC
Density: 1.55g/cm3
Storage Temp.:2-8°C
Vapor Pressure: 3.46E-06mmHg at 25°C
PKA: 4.50±1.00(Predicted)
PSA: 125.47000
LogP: 1.10090

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