- Schiff's Bases Formed between Pyridoxal 5'-Phosphate and 4-Aminobutanoic Acid. Kinetic and Thermodynamic Study
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The overall and individual kinetic constants of formation (k1 and k1i) and hydrolysis (k2, kOH and k2i) of the Schiff's bases formed between pyridoxal 5'-phosphate (PLP) and 4-aminobutanoic acid (GABA) at 10, 20, 25, 30, and 37 deg C, a variable pH and a constant ionic strength of 0.1 M (1 M = 1 mol dm-3) were determined. The formation of a Schiff's base is an intramolecular acid-catalyzed process. The activation and thermodynamic parameters for the formation and hydrolysis of the Schiff's bases were also determined. ΔH and ΔS for the individual processes were all found to be negative.
- Gorostidi, Gerardo R. Echevarria,Castellanos, M. Gabriela,Perez, Piedad Martin,Santos, Jose G.,Blanco, Francisco Garcia
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p. 523 - 528
(2007/10/03)
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- Transition-state analogues as inhibitors for GABA-aminotransferase
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Our previous calculations on the reaction catalysed by GABA-aminotransferase (GABA-T) have been utilized in this work in order to synthesize a series of reversible inhibitors of this enzyme.The synthesized transition-state analogues and their precursors i
- Iskander, MN,Andrews, PR,Winkler, DA,Brinkworth, RI,Paola, C Di,et al.
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p. 129 - 136
(2007/10/02)
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