- Oxone-sodium nitrite mediated N-nitrosamines formation under mild conditions from secondary amines
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Herein, we report an efficient synthesis of N-nitrosamines from cyclic, aliphatic, benzylic, and aromatic secondary amines via a novel straightforward, efficient, and mild chemical process using sodium nitrite and Oxone in methanol as a solvent at 0–5 °C. The demonstrated methodology accounts well for the parameters like cost-effective, short reaction time, clean and safe handling along with good to excellent yields.
- Gaur, Pinki,Banerjee, Shaibal
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p. 2270 - 2279
(2019/07/03)
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- Iodide-catalyzed synthesis of N-nitrosamines via C-N cleavage of nitromethane
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An iodide-catalyzed process to synthesize N-nitrosamines has been developed using TBHP as the oxidant. The mild catalytic system succeeded in cleaving the carbon-nitrogen bond in nitromethane. This methodology uses commercially available, inexpensive catalysts and oxidants and has a wide substrate scope and operational simplicity.
- Zhang, Jie,Jiang, Jiewen,Li, Yuling,Wan, Xiaobing
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p. 11366 - 11372
(2013/12/04)
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