- Azetidine-derived amino acids versus proline derivatives. Alternative trends in reverse turn induction
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(Figure Presented) The influence of 2-alkyl-2-carboxyazetidines (Aze) on the 3D structure of model tetrapeptides R2CO-2-R1Aze-L- Ala-NHMe has been analyzed by molecular modeling, 1H NMR, and FT-IR studies. The conformation
- Baeza, Jose Luis,Gerona-Navarro, Guillermo,De Vega, M. Jesus Perez,Garcia-Lopez, M. Teresa,Gonzalez-Muniz, Rosario,Martin-Martinez, Mercedes
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p. 1704 - 1715
(2008/09/20)
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- NOVEL AMINOPYRIMIDINE DERIVATIVES AS PLK1 INHIBITORS
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The present invention relates to a compound represented by Formula [I]: or a pharmaceutically acceptable salt or ester thereof, wherein R1 and R2, which may be the same or different, are each a hydrogen atom, a halogen atom, a lower
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Page/Page column 62
(2008/12/07)
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- Preparation and Use of Chloromethyl (-)-Menthyl Ether in the Synthesis of Optically Pure α-Branched α-Amino Nitriles
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The synthesis of optically pure chloromethyl (-)-menthyl ether (2b) and its use in the synthesis of di-(-)-menthyl acetal (-)-menthyl (+)-menthyl acetals are described.The diastereomeric mixed acetals 7a,b and 8a,b are easily obtainable from the nitrones 5 and 6, KCN and 2b.The mixture of diastereomers are separated into the pure components 7a, 7b and 8a, 8b by simple silica gel column chromatography.Hydrolysis of these products (H2O2/Na2CO3, ultrasound) followed by N-O cleavage affords the heterocyclic α-methyl-α-amino amides 11a, 11b and 12a, 12b.These are subsequently hydrolyzed to give the corresponding α-methyl-α-amino acids with S and R configuration, respectively.
- Shatzmiller, Shimon,Dolithzky, Ben-Zion,Bahar, Eliezer
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p. 375 - 379
(2007/10/02)
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