CONTINUOUS PROCESS FOR THE PREPARATION OF GABAPENTIN SALT
The present invention relates to the field of chemistry for the preparation of gabapentin salt of formula (I). More particularly the present invention relates to a continuous process for preparation of gabapentin salt (I) by means of the Hofmann rearrange
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Page/Page column 12-13
(2019/05/02)
PROCESS FOR PREPARING GABAPENTIN
The present invention provides compositions and methods of preparing gabapentin that includes (a) subjecting cyclohexanediacetic acid monoamide to a Hofmann rearrangement to yield a solution comprising an isocyanate intermediate; (b) hydrolyzing the isocyanate intermediate in the presence of an alkali base to form a gabapentin alkali salt; (c) converting the gabapentin alkali salt to a gabapentin-amine salt in a water-miscible polar solvent; (d) adding a basic or weakly basic ion exchange resin to a solution comprising the gabapentin-amine salt; (e) removing the ion exchange resin from the solution; and (f) concentrating the solution to yield gabapentin.
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Page/Page column 19
(2008/06/13)
Cyclic amino acids
The present invention is concerned with new cyclic amino acids and with the preparation thereof.
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(2008/06/13)
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