- A 3, 9 - perylene dicarboxylic acid preparation method
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The invention discloses a 3, 9 - perylene dicarboxylic acid of preparation method, specific step is ice-acetic acid in a solvent, in the dihydro e is obtained under the action of the sodium dichromate of 1, 8 - naphthalenedicarboxylic anhydride; 1, 8 - naphthalenedicarboxylic anhydride in saturated ammonia under the action of the acylation to obtain the 1, 8 - naphthalene asia amide; 1, 8 - naphthalene asia amide in potassium hydroxide and anhydrous sodium acetate manufacturing of the alkaline environment in the alkaline environment in C - C under high-temperature conditions obtained by coupling the 3, 4, 9, 10 - perylenetetracarboxylic acid diimide; 3, 4, 9, 10 - perylenetetracarboxylic acid diimide in under the action of the strong acid is converted into the 3, 4, 9, 10 - [...]; 3, 4, 9, 10 - [...] in microwave reactor in alkaline hydrolysis by the decarboxylation of 3, 9 - perylene dicarboxylic acid. The invention synthetic process more economic, environmental protection, high-efficient and simple.
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- Preparation method and application of novel perylene acid medicinal molecule with antineoplastic activity
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The invention discloses a preparation method and application of a novel perylene acid medicinal molecule with antineoplastic activity, and belongs to the technical field of pharmaceutical synthesis. The novel perylene acid medicinal molecule with antineoplastic activity is characterized by having the structural formula as shown in the description. The invention also provides a preparation method of the novel perylene medicinal molecule with the antineoplastic activity. The prepared perylene medicinal molecule has higher inhibiting activity for human cervical carcinoma Hela cells, human breastcancer MDA-MB-231 cells and human liver cancer HepG2 cells, and has the potential of becoming an antineoplastic medicament.
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- Preparation method and application of novel perylene drug molecule with biological activity
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The invention discloses a preparation method and application of a novel perylene drug molecule with the biological activity, and belongs to the technical field of medicine synthesis. According to thekey points of the technical scheme of the preparation method and application of the novel perylene drug molecule, the structural formula of the perylene drug molecule with the biological activity is as shown in the specification, wherein R is O or S. The invention further relates to the preparation method for the novel perylene drug molecule with the biological activity. The perylene drug moleculeprepared through the preparation method has good inhibitory activity on human cervical cancer hHela cells, human breast cancer MDA-MB-231 cells and human liver cancer HepG2 cells, is relatively low in toxicity on human normal cells and has the potential of becoming an anti-tumor drug.
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- Solvent-based green 5 isomer of the solvent-based dye
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The invention discloses a solvent dye composition for solving the problems of poor high-temperature resistance and limited application range of solvent green 5 in the prior art. The solvent dye composition is composed of the following components in percentage by mass: 85-88% of 3, 9-perylenedicarboxylic acid bis(2-methylpropyl) ester and 12-15% of 3, 10-perylenedicarboxylic acid bis(2-methylpropyl) ester. The solvent dye composition disclosed by the invention is simple and reasonable in component ratio, good in high-temperature resistance and capable of completely replacing a solvent green 5; the melting point of the solvent dye composition can be up to 328-330 DEG C. The invention also discloses a preparation method of the solvent dye composition. The preparation method comprises the following steps: (1) preparing 3, 9-perylenedicarboxylic acid and 3, 10-perylenedicarboxylic acid; (2) preparing 3, 9-perylenedicarboxylic acid bis(2-methylpropyl) ester and 3, 10-perylenedicarboxylic acid bis(2-methylpropyl) ester; (3) compounding. The preparation method disclosed by the invention is simple in process step, strong in operability, low in cost and suitable for industrial production.
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Paragraph 0015; 0016
(2017/04/03)
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