- Asymmetric synthesis of β-hydroxy sulfonic acids by BINAP/Ru-catalyzed hydrogenation
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BINAP/Ru(II) complexes catalyze enantioselective hydrogenation of sodium β-keto sulfonates in acidic methanol tinder atmospheric pressure of hydrogen at 50 °C to give the corresponding β-hydroxy sulfonates with up to 97% ee in a quantitative yield. The sense of asymmetric induction is predictable. The low-pressure hydrogenation process allows the hectogram-scale synthesis of a variety of optically active β-hydroxy sulfonates, which attract attention in connection with their functions as surfactants, catalysts, enzyme inhibitors, etc.
- Kitamura, Masato,Yoshimura, Masahiro,Kanda, Naoki,Noyori, Ryoji
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- Specific intramolecular aromatic C–H insertion of diazosulfonamides
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The chemoselectivity in the intramolecular C–H insertion of various diazosulfonamides has been experimentally studied. The results reveal that the aliphatic 1,4-, 1,5-, or 1,6-C(sp3)?H insertions of diazosulfonamides are not accessible, while t
- Huang, Peipei,Yang, Zhanhui,Xu, Jiaxi
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p. 3255 - 3265
(2017/05/12)
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- New heterocyclic precursors for thermal generation of reactive, electron-rich 1,2-diaza-1,3-butadienes
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Figure presented The preparation and thermolysis of new stable heterocyclic precursors of 1,2-diaza-1,3-butadienes is described. The resulting reactive diazadienes are trapped in situ with N-phenyldiazamaleimide. The effect of precursor structure on the temperature at which the diazadienes are generated is discussed.
- Boeckman Jr., Robert K.,Ge, Ping,Reed, Jessica E.
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p. 3647 - 3650
(2007/10/03)
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- DL CAMPHOR 3-SULFONIC ACID AND OTHER KETO &α-SULFONIC ACIDS
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Sulfur trioxide-dioxan reagent has been used to convert acetophenone, 4-t-butylcyclohexanone, DL camphor and menthone to the α-sulfonic acids (3,5,2 and 12).Attempts to convert 3,5 and 12 to the corresponding sulfonyl chlorides were unsuccessful.However,
- Cremlyn, Richard J.,Wu, Luke
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p. 165 - 172
(2007/10/02)
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