Synthesis of N-<2-(6-Chloro-5-methoxy-1H-indol-3-yl)ethyl-acetamide (6-Chloromelatonin)
-
Huegel, Helmut M.
p. 935 - 936
(2007/10/02)
Synthesis and evaluation of the antiovulatory activity of a variety of melatonin analogues
A series of melatonin analogues was synthesized and examined for ovulation-blocking activity. Deviation from the 5-methoxy group or substitution of the 1 position prevented activity. Activity was not particularly sensitive to minor variations in the N-acyl group nor was it significantly altered by methylation of position 2 or the α-methylene; however, a pronounced enhancement resulted from halogenation of the 6 position.
Flaugh,Crowell,Clemens,Sawyer
p. 63 - 69
(2007/10/04)
Amides as ovulation inhibitors
N-[2-(5-methoxy-6-haloindol-3-yl)ethyl]amides are valuable, orally active, ovulation inhibitors.
-
(2008/06/13)
More Articles about upstream products of 63762-74-3