Isolation and characterization of the product of inactivation of γ-aminobutyric acid aminotransferase by gabaculine
Gabaculine (5-amino-1,3-cyclohexadienylcarboxylic acid, 1Scheme 1), a naturally occurring neurotoxin isolated from Streptomyces toyocaenis, has been shown to be a mechanism-based inactivator of γ-aminobutyric acid aminotransferase (GABA-AT) (Rando, R. R.
Transition-state analogues as inhibitors for GABA-aminotransferase
Our previous calculations on the reaction catalysed by GABA-aminotransferase (GABA-T) have been utilized in this work in order to synthesize a series of reversible inhibitors of this enzyme.The synthesized transition-state analogues and their precursors i
Iskander, MN,Andrews, PR,Winkler, DA,Brinkworth, RI,Paola, C Di,et al.
p. 129 - 136
(2007/10/02)
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