cas 63861-26-7, Cyclopentanecarboxylic acid, 2,2-dimethyl- | Articles data ｜lookchem

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63861-26-7

Articles about 63861-26-7Total 3 be found

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5-MEMBERED HETEROARYLAMINOSULFONAMIDES FOR TREATING CONDITIONS MEDIATED BY DEFICIENT CFTR ACTIVITY
The invention relates to heteroaryl compounds, pharmaceutically acceptable salts thereof, and pharmaceutical preparations thereof. Also described herein are compositions and the use of such compounds in methods of treating diseases and conditions mediated by deficient CFTR activity, in particular cystic fibrosis.
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(2021/05/21)

Intramolecular S(N)2' cyclization of an alkyllithium species onto a methoxy allyl ether is syn selective.
The preference for syn- or anti-addition of an intramolecular S(N)2[prime or minute] cyclization of an alkyllithium species onto a methoxy allyl ether has been proven unequivocally to take place by a syn S(N)2[prime or minute] mechanism.
La Cruz, Thomas E,Rychnovsky, Scott D
p. 168 - 169
(2007/10/03)

Design and synthesis of 4-substituted benzamides as potent, selective, and orally bioavailable IKs blockers
Multiple delayed rectifier potassium currents, including IKs, are responsible for the repolarization and termination of the cardiac action potential, and blockers of these currents may be useful as antiarrhythmic agents. Modification of compound 5 produced 19(S) that is the most potent IKs blocker reported to date with > 5000-fold selectivity over other cardiac ion channels. Further modification produced 24A with 23% oral bioavailability.
Lloyd,Schmidt,Rovnyak,Ahmad,Atwal,Bisaha,Doweyko,Stein,Traeger,Mathur,Conder,DiMarco,Harper,Jenkins-West,Levesque,Normandin,Russell,Serafino,Smith,Lodge
p. 3764 - 3767
(2007/10/03)

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Chemical Properties

Boiling Point: 227.8 °C at 760 mmHg
Flash Point:107.3 °C
Density: 1.02 g/cm³
PKA: 4.82±0.40(Predicted)
PSA: 37.30000
LogP: 1.89730

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