- Synthesis of cyclic cis-enediynes from manganese carbyne complexes and α,ω-diynes
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Cyclic cis-enediynes are readily prepared by a two-step one-pot procedure. The first step is the copper-catalyzed addition of α,ω-diynes to manganese carbyne complexes to give intermediate bis(alkynylcarbene) complexes that rearrange to enediyne complexes below room temperature. In the second step, the free enediyne is released from manganese by photolysis, copper-catalyzed air oxidation, or stoichiometric Cu(II) oxidation. These new procedures have been applied to a variety of five-, six-, and seven-membered-ring cyclic enediynes containing a range of ether, ester, and ketone functional groups.
- Casey, Charles P.,Dzwiniel, Trevor L.,Kraft, Stefan,Guzei, Ilia A.
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p. 3915 - 3920
(2008/10/08)
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- Manganese Trifluoroacetoxycarbene Complexes are Convenient Intermediates in the Synthesis of Cyclic Enediynes
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The use of trifluoroacetoxycarbene complexes as an alternative to thermally sensitive manganese carbyne complexes for the synthesis of cyclic enediynes was discussed. The complexes were generated from the reaction of stable manganese acyl complexes with t
- Casey, Charles P.,Dzwiniel, Trevor L.
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p. 5285 - 5290
(2008/10/09)
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