A facile method for the synthesis of thiocarbamates: Palladium-catalyzed reaction of disulfide, amine, and carbon monoxide
(Equation Presented) A new method for the synthesis of thiocarbamates has been developed. When dialkyl or diaryl disulfides were allowed to react with secondary amines and carbon monoxide in the presence of a catalytic amount of a palladium complex, the thiocarbamates were obtained in moderate to good yields. In contrast to that of secondary amines, in the reaction of a primary amine, no formation of thiocarbamate was confirmed, but urea was formed in good yield.
Conversion of sterically hindered phenols into the corresponding N,N-dimethylarenesulfonamides via the Newman-Kwart rearrangement
The 2-alkyl- and 2,6-dialkylbenzenesulfonyl chlorides 5a-f were obtained in high yield by chlorination of the correspondingly substituted S-aryl N,N-dialkylthiocarbamates 4a-g.These precursors have been synthesized via the Newman-Kwart rearrangement of th
Wagenaar, Anno,Engberts, Jan B. F. N.
p. 91 - 94
(2007/10/02)
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