- HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF
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Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, or pharmaceutically acceptable salts thereof, compositions thereof, and methods of their use. The condition or disorder mediated by HDAC comprises a neurodegenerative pathology. Accordingly, also provided is a method of treating a neurodegenerative pathology mediated by HDAC in a subject in need of such a treatment, comprising administering to the subject a therapeutically effective amount of at least one compound, or pharmaceutically acceptable salt thereof, described herein.
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Paragraph 00170
(2015/12/30)
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- Inter-and intramolecular annulation strategies to a cyclopentanone building block containing an all-carbon quaternary stereogenic center
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Synthesis of (S)-2-methyl-3-fluorophenyl cyclopentanone methyl ester (1S)-1 has been achieved by both inter-and intramolecular alkylation reactions on multigram scale, using chiral pool reagents. The intramolecular variant is a novel example of a chiral bis-electrophile reacting with a carbon nucleophile to form an enantiomerically pure all-carbon quaternary center.
- Penrose, Stephen D.,Stott, Andrew J.,Breccia, Perla,Haughan, Alan F.,Bürli, Roland W.,Jarvis, Rebecca E.,Dominguez, Celia
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supporting information
p. 1401 - 1404
(2015/03/30)
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- HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS
-
Provided are certain histone deacetylase (HDAC) inhibitors of Formula (I), compositions thereof, and methods of their use.
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Paragraph 00149
(2014/10/15)
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- HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF
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Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
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Paragraph 00144
(2014/10/15)
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