SEQUENCE OF ALKYLATION OF CYCLOHEXANE-1,3-DIONE. ALTERNATIVE SYNTHESIS OF (+/-)-ANGUSTIONE
A method is proposed for introducing one, two, or three alkyl substituents into positions 4 and 6 of the cyclohexane-1,3-dione molecule by successive alkylation under the action of strong bases. (+/-)-Angustione (a natural β-diketone) has been synthesized.
Zenyuk, A. A.,Lis, L. G.,Ukhova, L. I.
p. 400 - 403
(2007/10/02)
SYNTHESIS OF (+/-)-ANGUSTIONE BY THE REGIOSELECTIVE ALKYLATION OF ENAMINODIKETONES UNDER THE ACTION OF STRONG BASES
The synthesis of (+/-)-angustione has been carried out on the basis of a method that we have developed for the regio- and stereoselective alkylation of enaminodiketones of the cyclohexane series.
Zenyuk, A. A.,Korchuk, A. V.,Ukhova, L. I.,Lis, G. L.