- The Chemical Structure and the Mutagenicity of Emodin Metabolites
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Emodin (1,3,8-trihydroxy-6-methyl-9,10-anthraquinone) is a natural occuring anthraquinone formed in rhubarb and fungal metabolites.Emodin was transformed into 6 major metabolites by rat hepatic microsomes.The metabolites were identified as 2-hydroxyemodin, 4-hydroxyemodin, 5-hydroxyemodin, 7-hydroxyemodin, ω-hydroxyemodin, and emodic acid by comparison with the synthetic compounds using thin-layer chromatography.It was clear that 2-hydroxyemodin is a proximate mutagen as a synthetic compound by the Salmonella assay.Other metabolites, such as 5-hydroxyemodin and ω-hydroxyemodin, became active after metabolic activation, but 4-hydroxyemodin and emodic acid were inactive either in the presence or in the absence of the metabolic activation system.
- Morooka, Nobuhisa,Nakano, Sonoko,Itoi, Noriko,Ueno, Yoshio
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p. 1247 - 1252
(2007/10/02)
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- Studies on the Constituents of the Seeds of Cassia obtusifolia LINN. The Structures of Two New Anthraquinone Glycosides
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Two new athraquinones, alaternin 1-O-β-D-glucopyranoside and chryso-obtusin 2-O-β-D-glucopyranoside, were isolated, along with physcion 8-O-β-D-glucopyranoside, from the seeds of Cassia obtusifolia LINN., and their structures were established on the basis of spectral and chemical evidence.Keywords - Cassia obtusifolia; Leguminosae; anthraquinone glucoside; physcion 8-O-β-D-glucopyranoside; alaternin 1-O-β-D-glucopyranoside; chryso-obtusin 1-O-β-D-glucopyranoside
- Kitanaka, Susumu,Kimura, Fumie,Takido, Michio
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p. 1274 - 1276
(2007/10/02)
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