- Site-Specific Oxidation of (sp3)C-C(sp3)/H Bonds by NaNO2/HCl
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A site-specific oxidation of (sp3)C-C(sp3) and (sp3)C-H bonds in aryl alkanes by the use of NaNO2/HCl was explored. The method is chemical-oxidant-free, transition-metal-free, uses water as the solvent, and proceeds under mild conditions, making it valuable and attractive to synthetic organic chemistry.
- Zhao, Jianyou,Shen, Tong,Sun, Zhihui,Wang, Nengyong,Yang, Le,Wu, Jintao,You, Huichao,Liu, Zhong-Quan
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p. 4057 - 4061
(2021/05/26)
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- Deprotection of durable benzenesulfonyl protection for phenols — efficient synthesis of polyphenols
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A robust protection method for phenol was demonstrated by the use of durable benzenesulfonyl group, which survives various harsh reaction conditions using Grignard reagent, organolithium reagent, metal alkoxide, phosgene, mineral, and Lewis acids. A facile deprotection condition utilizing pulverized KOH (5 equiv) and t-BuOH (10 equiv) in hot toluene makes this protocol as a practical method, which can be applied to the multistep synthesis of biologically and medicinally important polyphenol compounds.
- Alam, Mohammad Shariful,Koo, Sangho
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supporting information
p. 247 - 254
(2018/01/08)
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- Comparative Study of the Limitations and Challenges in Atom-Transfer C-H Oxidations
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A comparative study is disclosed that seeks to highlight the current limitations and challenges that exist in the field of atom-transfer C-H oxidations. State-of-the-art methods are benchmarked in order to showcase clear differences and similarities. A novel Mn-mediated method for C-H oxidation is disclosed that serves as a rapid and simple method for aliphatic C-H hydroxylation. Finally, two methods that allow for C-H oxidation in the presence of pyridine-containing substrates are studied, something that is rare in the field but of great interest to the chemical community.
- Adams, Ashley M.,Du Bois,Malik, Hasnain A.
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supporting information
p. 6066 - 6069
(2016/01/09)
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- Organocatalytic C-H hydroxylation with Oxone enabled by an aqueous fluoroalcohol solvent system
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Selective hydroxylation of 3° and benzylic C-H bonds is made possible using a non-metal-based catalyst system, Oxone as the terminal oxidant, and an aqueous fluoroalcohol solvent mixture. The choice of solvent is uniquely effective for this process, but s
- Adams, Ashley M.,Du Bois
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p. 656 - 659
(2014/01/17)
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- Total synthesis of (-)-blepharocalyxin D and analogues
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An efficient strategy for the total synthesis of (-)-blepharocalyxin D and an analogue is described. The key step involves an acid-mediated cascade process in which reaction of methyl 3,3-dimethoxypropanoate with γ,δ- unsaturated alcohols possessing diastereotopic styrenyl groups gives trans-fused bicyclic lactones with the creation of two rings and four stereocenters in one pot.
- Cons, Benjamin D.,Bunt, Adam J.,Bailey, Christopher D.,Willis, Christine L.
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supporting information
p. 2046 - 2049
(2013/06/05)
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- Chemoselective regulation of TREK2 channel: Activation by sulfonate chalcones and inhibition by sulfonamide chalcones
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Although it has not been extensively studied, a significant volume of literature suggests that TREK2 will probably turn out to be an important channel in charge of tuning neuronal transmitter and hormone levels. Thus, pharmacological tools which can manip
- Kim, Eun-Jin,Ryu, Hyung Won,Curtis-Long, Marcus J.,Han, Jaehee,Kim, Jun Young,Cho, Jung Keun,Kang, Dawon,Park, Ki Hun
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supporting information; experimental part
p. 4237 - 4239
(2010/08/22)
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- Sulfonate chalcone as new class voltage-dependent K+ channel blocker
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Chalcone derivatives 1-17 were synthesized and their voltage-dependent K+ channel inhibitory activities were investigated. The effective K+ channel blockers were shown to be sulfonate chalcones 9-17, in which the sulfonyloxy group is
- Yarishkin, Oleg V.,Ryu, Hyung Won,Park, Jae-Yong,Yang, Min Suk,Hong, Seong-Geun,Park, Ki Hun
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p. 137 - 140
(2008/09/16)
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