- Novel chemistry of α-tosyloxy ketones: Applications to the solution- and solid-phase synthesis of privileged heterocycle and enediyne libraries
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New synthetic technologies for the preparation and elaboration of α-tosyloxy ketones in solution and on solid-phase are described. Both olefins and ketones serve as precursors to these relatively stable chemical entities: olefins via a novel one-pot epoxi
- Nicolaou,Montagnon,Ulven,Baran,Zhong,Sarabiat
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p. 5718 - 5728
(2007/10/03)
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- NEW METHOD FOR THE PRODUCTION OF 1,4-DIOXACYCLOHEXADECANE-5,16-DIONE FROM CYCLODECANONE
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A new method is proposed for the synthesis of 1,4-dioxacyclohexadecane-5,16-dione by the oxidation of 13,16-dioxabicyclohexadec-1(12)-ene, obtained from 2-hydroxycyclododecanone and ethylene glycol.The action of an aqueous or alcohol solution of potassium hydroxide on 2-acetoxy- or 2-hydroxycyclododecanone leads to oxidative cleavage of the C-C bond with the formation of 1,10-decanedicarboxylic acid.
- Zakharkin, L. I.,Guseva, V. V.
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p. 115 - 118
(2007/10/02)
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