- Preparation method 2 -amino -5 -fluorobenzonitrile
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The invention discloses a preparation method of 2 - amino -5 - fluorobenzonitrile, which comprises the specific steps of (1) taking 2, 5 - difluorobenzaldehyde as a starting raw material, condensation reaction with hydroxylamine hydrochloride under the conditions of triethylamine, and generating compound III. (2) Compound III is dehydrated with phosphorus oxychloride to form compound IV. (3) Compound IV is decomposed by ammonia to form compound I. That is 2 - amino -5 - fluorobenzonitrile. The preparation method is higher in yield.
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Paragraph 0027; 0030; 0034; 0037; 0039; 0041
(2021/09/08)
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- Zn-catalyzed cyanation of aryl iodides
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We report the first example of zinc-catalyzed cyanation of aryl iodides with formamide as the cyanogen source. The transformation was promoted by the bisphosphine Nixantphos ligand. Under optimized conditions, a variety of electron-donating and electron-withdrawing aryl iodides were converted into nitrile products in good to excellent yields. This approach is an exceedingly simple and benign method for the synthesis of aryl nitriles and is likely to proceed via a dinuclear Zn-concerted catalysis.
- Zhao, Lulu,Dong, Yanan,Xia, Qiangqiang,Bai, Jianfei,Li, Yuehui
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p. 6471 - 6477
(2020/06/08)
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- Synthesis of 2-fluoro-5-polybromide method of terephthalic acid
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The invention discloses a method for synthesizing 2-fluoro-5-bromoterephthalic acid, which comprises the following steps: dissolving 2,5-dichlorobenzonitrile and dry potassium fluoride in sulfolane, and heating to react to obtain 2,5-difluorobenzonitrile (the purity is 99%); adding a new sulfolane solution, and introducing chlorine for 2 hours to obtain 6-amino-2-fluorobenzonitrile; carrying out diazotization treatment, adding acrylonitrile and hydrobromic acid, heating to react, and extracting with ethyl acetate for dilution to obtain 2-fluoro-5-bromo-p-benzonitrile; and finally, carrying out hydrolysis on the 2-fluoro-5-bromo-p-benzonitrile in a dilute sulfuric acid water solution for 8 hours, and extracting with ethyl acetate to obtain 15.44g of 2-fluoro-5-bromoterephthalic acid, wherein the yield is 83.99% above.
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Paragraph 0015
(2017/04/26)
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- N-indazolyl[1,2,4]triazolo[1,5-C]pyrimidine-2-sulfonamide herbicides
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Substituted N-indazolyl[1,2,4]triazolo[1,5]-c-pyrimidine-2-sulfonamide compounds, such as N-(4-fluoro-1-methyl-3-indazolyl)-5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide, were prepared by condensation of a 2-chlorosulfonyl[1,2,4]triazolo[1,5-c]pyrimidine compound, such as 2-chlorosulfonyl-5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine, with a substituted 3-aminoindazole compound, such as 3-amino-4-fluoro-1-methylindazole, and found to possess herbicidal utility.
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- General and Highly Efficient Syntheses of m-Fluoro Arenes Using Potassium Fluoride-Exchange Method
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Tetraphenylphosphonium bromide was found to be a suitable catalyst for the reaction of m-nitroaryl derivatives carrying cyano, nitro, chlorocarbonyl, trifluoromethyl, and chlorosulfonyl groups with potassium fluoride in the presence of a stoichiometric amount of phthaloyl dichloride, giving the corresponding m-fluoro aromatic derivatives in good yields.The catalyst was also found to be efficient for the fluorodesulfonylation of m-(fluorosulfonyl)aryl derivatives to afford m-fluoro arenes by the use of a reaction-distillation technique.
- Suzuki, Hiroshi,Yazawa, Naoto,Yoshida, Yasuo,Furusawa, Osamu,Kimura, Yoshikazu
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p. 2010 - 2017
(2007/10/02)
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