New Derivatives of Kanamycin B Obtained by Modifications and Substitutions in Position 6''. 1. Synthesis and Microbiological Evaluation
The clinical use of the potent, wide-spectrum aminoglycoside antibiotics is limited by oto- and nephrotoxicities.The latter is related to the binding of these polycationic drugs to negatively charged phospholipids and to the subsequent inhibition of lysos
Schepdael, A. Van,Delcourt, J.,Mulier, M.,Busson, R.,Verbist, L.,et al.
p. 1468 - 1475
(2007/10/02)
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