- Preparation of trifluorovinyl compounds by lithium salt-promoted monoalkylation of tetrafluoroethene
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Treatment of tetrafluoroethene (TFE) with diethylzinc in the presence of lithium iodide gave 1,1,2-trifluoro-1-butene in moderate yield. In the absence of lithium iodide, however, the nucleophilic addition of diethylzinc to TFE proceeded very slowly to afford ethyl 1,1,2,2-tetrafluorobutylzinc. The addition of lithium iodide to a solution of ethyl-1,1,2,2-tetrafluorobutylzinc resulted in a smooth transformation into 1,1,2-trifluoro-1-butene. In the presence of lithium chloride, the reaction of TFE with benzyl or allyl Grignard reagents afforded the corresponding monosubstituted products in good to excellent yields.
- Ohashi, Masato,Kamura, Ryohei,Doi, Ryohei,Ogoshi, Sensuke
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supporting information
p. 933 - 935
(2013/09/02)
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- METHOD FOR PRODUCING SUBSTITUTED FLUORINE-CONTAINING OLEFIN
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This invention relates to a method of reacting fluoroolefin with an organic magnesium compound in the presence of a catalyst comprising nickel or palladium so as to efficiently produce fluoroolefin, such as TFE, in which a fluorine (F) atom or atoms bonded to the sp2 hybridized carbon atom are substituted with an organic group.
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Page/Page column 2
(2013/02/28)
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- Reaction of fluoro(phenyl)carbene with Schiff bases: Synthesis of 2-fluoro-2-phenylaziridines
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Fluoro(phenyl)carbene generated by reaction of α-bromo-α- fluorotoluene with potassium tert-butoxide reacts with Schiff bases to afford the corresponding 2-fluoro-2-phenylaziridines. The latter were isolated in low yields due to their instability under the carbene generation conditions. Although the reaction of α,α-dibromo-α-fluorotoluene with zinc and lead involves formation of fluoro(phenyl)carbene, this procedure is not suitable for the synthesis of 2-fluoro-2-phenylaziridines. 2005 Pleiades Publishing, Inc.
- Kusei,Novikov,Khlebnikov
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p. 1643 - 1647
(2007/10/03)
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