- Preparation method of dopamine hydrochloride
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The invention provides a method which comprises the following steps: taking veratraldehyde as a starting raw material, firstly carrying out condensation reaction with nitromethane to generate 3, 4-dimethoxy-beta-nitrostyrolene, carrying out catalytic reduction to obtain 3, 4-dimethoxy phenylethylamine, carrying out reaction with hydrobromic acid to remove methoxy, and finally salifying with hydrochloric acid to obtain dopamine hydrochloride. The preparation method has the advantages of cheap and easily available initial raw materials, simple process, no high-temperature and high-pressure steps, low cost, high purity and high yield, and is suitable for industrial production.
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- Method for efficiently preparing 5,6-dihydroxyindole (by machine translation)
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The preparation method 5,6 - of the compound,dihydroxyindole comprises the following steps :(1): dissolving 3,4 - dialkoxybenzylethylamine and a catalyst in an organic solvent, in an organic solvent, carrying out reflux reaction, in the heated stirring state ;(2) and then further purifying to obtain (1)-hydroxyindole solid powder, which is suitable for industrial production, and has a high, product purity, stability, and easy long-term storage after the operation steps, are short ;(3) reaction steps, through an oxidation reaction, and then further purifying the intermediate compound I, and then purifying the compound I by the oxidizing agent, and then purifying the intermediate compound. I by using a, reducing agent, and then, purifying the intermediate compound I by the, oxidation reaction step 5,6 - and further, purifying the obtained dopamine white solid, powder . by oxidation reaction . The method comprises the following steps. (by machine translation)
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Paragraph 0040-0044
(2020/04/29)
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- Synthetic method of high-purity dopamine hydrochloride
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The invention provides a synthetic method of dopamine hydrochloride, and belongs to the field of drug synthesis. The preparation method comprises the following steps: taking 3,4-dimethoxyphenylethylamine as an initial raw material, firstly reacting with an acid to form a salt, re-crystallizing and refining to obtain 3,4-dimethoxyphenylethylamine salt, reacting with hydrobromic acid to remove methyl to generate dopamine hydrobromide, and finally reacting with hydrochloric acid to form a salt so as to obtain dopamine hydrochloride. The preparation method provided by the invention has the advantages of cheap and easily available initial raw materials, simple process, no high-temperature and high-pressure hydrogenation step, low cost, high purity and high yield, and is suitable for industrialproduction.
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