- BIOTIN STANNANE FOR HPLC-FREE RADIOIODINATION
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The present teachings provide methods that enable the preparation and purification of radioiodinated vectors without the need for HPLC purification, as well as novel precursors which include biotin-like substituents useful in such methods.
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Paragraph 0105; 0106
(2013/10/08)
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- PROCESS FOR PRODUCTION OF ALKYL TIN ALKOXIDE COMPOUND, AND PROCESS FOR PRODUCTION OF CARBONATE ESTER USING THE COMPOUND
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The present invention provides a process for producing : a compound represented by XOR2; a dialkyl tin dialkoxide compound having one tin atom, two Sn-R1 bonds and two Sn-OR2 bonds; and/or a tetraalkyl dialkoxy distannoxane compound having one Sn-O-Sn bond, in which each tin atom of the tetraalkyl dialkoxy distannoxane compound has two Sn-R1 bonds and one Sn-OR2 bond, the process comprising reacting in the absence of a catalyst at least one alkyl tin compound selected from the group consisting of i) and ii) below: i) a dialkyl tin compound having one tin atom, two Sn-R1 (wherein R1 represents an alkyl group) bonds, and two Sn-OX bonds (wherein OX is a group in which HOX that is a conjugate acid of OX is a Bronsted acid having a pKa of from 0 to 6.8); and ii) a tetraalkyl distannoxane compound having one Sn-O-Sn bond, in which each tin atom of the tetraalkyl distannoxane compound has two Sn-R1 bonds and one Sn-OX bond (wherein OX is a group in which HOX that is a conjugate acid of OX is a Bronsted acid having a pKa of from 0 to 6.8); and a carbonic acid ester represented by R2OCOOR2 (wherein R2 represents a linear or branched, saturated or unsaturated hydrocarbon group, a hydrocarbon group having a saturated or unsaturated cyclic hydrocarbon substituent, or a Y-CH2- group (wherein Y represents an alkyl polyalkylene group, an aromatic group or a cyclic saturated or unsaturated alkylene ether group)), and/or an alcohol represented by R2OH (wherein R2 is the same as defined above).
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Page/Page column 65
(2010/09/17)
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- Process for Production of Alkyl Tin Alkoxide Compound, and Process for Production of Carbonic Acid Ester Using the Compound
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The present invention provides a process for producing: a compound represented by XOR2; a dialkyl tin dialkoxide compound having one tin atom, two Sn—R1 bonds and two Sn—OR2 bonds; and/or a tetraalkyl dialkoxy distannoxane compound having one Sn—O—Sn bond, in which each tin atom of the tetraalkyl dialkoxy distannoxane compound has two Sn—R1 bonds and one Sn—OR2 bond, the process comprising reacting in the absence of a catalyst at least one alkyl tin compound selected from the group consisting of i) and ii) below: i) a dialkyl tin compound having one tin atom, two Sn—R1 (wherein R1 represents an alkyl group) bonds, and two Sn—OX bonds (wherein OX is a group in which HOX that is a conjugate acid of OX is a Bronsted acid having a pKa of from 0 to 6.8); andii) a tetraalkyl distannoxane compound having one Sn—O—Sn bond, in which each tin atom of the tetraalkyl distannoxane compound has two Sn—R1 bonds and one Sn—OX bond (wherein OX is a group in which HOX that is a conjugate acid of OX is a Bronsted acid having a pKa of from 0 to 6.8); anda carbonic acid ester represented by R2OCOOR2 (wherein R2 represents a linear or branched, saturated or unsaturated hydrocarbon group, a hydrocarbon group having a saturated or unsaturated cyclic hydrocarbon substituent, or a Y—CH2— group (wherein Y represents an alkyl polyalkylene group, an aromatic group or a cyclic saturated or unsaturated alkylene ether group)), and/oran alcohol represented by R2OH (wherein R2 is the same as defined above).
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Page/Page column 48-49
(2010/12/18)
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- HETEROGENEOUS ORGANOTIN CATALYSTS
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Supported heterogeneous organotin catalysts of the formula X1, X2, or X3: wherein Z is a spacer group; Y is an insoluble phenyl-group containing copolymer; R1, R2, R3, R5, and R6 are independently selected from halogen, alkyl, alkylene, phenyl, vinyl, allyl, naphthyl, aralkyl, and Z; and R4 is alkyl, alkylene, phenyl, vinyl, allyl, naphthyl, or aralkyl.
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Page/Page column 4
(2010/06/22)
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- Stille cross-coupling reactions with tin reagents supported on ionic liquids
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New ionic-liquid-supported tin reagents were synthesized and used in Stille cross-coupling reactions. High yields of biaryls were obtained under low-temperature, solvent-free, ligand-free conditions, with simple purification techniques. Moreover, the tin compound could be recycled up to five times without significant loss of reactivity. An expanded catalytic cycle for the Stille cross coupling reaction is proposed in order to explain side products that were formed under certain reaction conditions.
- Pham, Phuoc Dien,Vitz, Juergen,Chamignon, Cecile,Martel, Arnaud,Legoupy, Stephanie
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experimental part
p. 3249 - 3257
(2009/12/24)
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- A convenient quick synthesis of SnBu2RCl derivatives
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A convenient method for the quick preparation of SnBu2RX (Bu = n-Bu) has been developed using microwave irradiation and column chromatography in acidic alumina. The method can be a good alternative particularly for easy and quick preparation of
- Carrera, Nora,Monica,Perez-Temprano,Albeniz, Ana C.,Casares, Juan A.,Espinet, Pablo
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p. 3957 - 3958
(2009/12/08)
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- A novel mode of access to polyfunctional organotin compounds and their reactivity in Stille cross-coupling reaction
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Mono-, di-, tri- and tetra-functional organotin compounds were easily prepared in a sonicated Barbier reaction using ultrasound technology via coupling reaction of organo halides with tin halides (Bu3SnCl, Bu2SnCl2, BuSnCl
- Lamandé-Langle, Sandrine,Abarbri, Mohamed,Thibonnet, Jér?me,Duchêne, Alain
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p. 2368 - 2374
(2009/09/30)
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- Arylation of organotin halides with pentaarylantimony and pentaphenylbismuth
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Pentaarylantimony and pentaphenylbismuth arylate oranotin halides R3SnX and R2SnX2 (R = Alk, Ar; X = Cl, Br) in toluene at room temperature to aryltin derivatives R3SnAr and R2SnArX (initial reagent molar ratio 1:1) or R2SnAr2 (2:1) in 78-95% yield.
- Sharutin,Sharutina,Senchurin,Kovaleva,Shcherbakov,Gladyshev
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- Reactions of Organoytterbium Compounds RYbI (R = Me, Et, Ph) with Organotin Oxides and Acetates
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Reactions of RYbI (R = Me, Et, Ph) with organotin oxides and acetates) involve cleavage of the Sn-O bonds to form tetrasubstituted stannanes mostly as single or main reaction products (yields 65-96 percent). A similar results was obtained in reaction of PhYbI with diphenyltin sulfide (yield 93 percent). However, reactions of RYbI (R = Me, Et, Ph) with Bu2SnO, followed by hydrolysis of the reaction mixtures lead to hydroxystannanoxanes Bu2RSnOH in 66-75 percent yields.
- Rybakova, L. F.,Syutkina, O. P.,Novgorodova, M. N.,Petrov, E. S.
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- Preparation and properties of unsymmetrical tetraorganotin compounds
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Unsymmetrical tetraorganotins, R2R1R2Sn (R=Me, R1=Bu, R2=Pe (Pe=pentyl) or Ph; R=Bu, R1=Pe, R2=Ph or Me; R=Pe, R1=Bu, R2=Me or Ph), BunR4-nSn (n=1-3, R=Me or Pe) and Pe2R2Sn (R=Me or Ph) have been synthesised.Various physical properties, including mass spectra, 1H and 13C NMR spectra, are reported.
- Marr, Iain L.,Rosales, Daniel,Wardell, James L.
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