- Hydrosilylation of 1-hexyne promoted by acetone solvated gold atoms derived catalysts
-
Supported gold nanoparticles, prepared by deposition of acetone solvated Au atoms on supports as carbon and γ-Al2O3, behave as valuable catalysts for the regioselective hydrosilylation of 1-hexyne with different silanes. The catalytic behaviour of gold-based systems is compared with the activity of supported platinum catalysts and a different affinity between the metals and the silanes is observed.
- Caporusso, Anna Maria,Aronica, Laura Antonella,Schiavi, Eleonora,Gianmario Martra,Vitulli, Giovanni,Salvadori, Piero
-
-
Read Online
- Direct Access to α,β-Unsaturated Ketones via Rh/MgCl2-Mediated Acylation of Vinylsilanes
-
We report herein the facile and practical construction of α,β-unsaturated ketones via rhodium-catalyzed direct acylation of vinylsilanes with readily available and abundant carboxylic acids. This protocol features access to a diverse array of synthetically useful functionalities with moderate to excellent yields. More importantly, the late-stage functionalization of pharmaceuticals was also realized with synthetically useful yield.
- Chen, Zi-Yan,Deng, Xue-Zu,Song, Yang,Xue, Fei,Yamane, Motoki,Yue, Yan-Ni
-
p. 12693 - 12704
(2021/09/28)
-
- Iridium(i) complexes bearing hemilabile coumarin-functionalised N-heterocyclic carbene ligands with application as alkyne hydrosilylation catalysts
-
A set of iridium(i) complexes of formula IrCl(κC,η2-IRCouR′)(cod) or IrCl(κC, η2-BzIRCouR′)(cod) (cod = 1,5-cyclooctadiene; Cou = coumarin; I = imidazolin-2-carbene; BzI = benzimidazolin-2-carbene) have beeen prepared from the corresponding azolium salt and [Ir(μ-OMe)(cod)]2 in THF at room temperature. The crystalline structures of 4b and 5b show a distorted trigonal bipyramidal configuration in the solid state with a coordinated coumarin moiety. In contrast, an equilibrium between this pentacoordinated structure and the related square planar isomer is observed in solution as a consequence of the hemilability of the pyrone ring. Characterization of both species by NMR was achieved at the low and high temperature limits, respectively. In addition, the thermodynamic parameters of the equilibrium, ΔHR and ΔSR, were obtained by VT 1H NMR spectroscopy and fall in the range 22-33 kJ mol-1 and 72-113 J mol-1 K-1, respectively. Carbonylation of IrCl(κC,η2-BzITolCou7,8-Me2)(cod) resulted in the formation of a bis-CO derivative showing no hemilabile behaviour. The newly synthesised complexes efficiently catalyze the hydrosilylation of alkynes at room temperature with a preference for the β-(Z) vinylsilane isomer.
- ?zdemir, Ismail,Alici, Bülent,Castarlenas, Ricardo,Karata?, Mert Olgun,Pérez-Torrente, Jesús J.,Passarelli, Vincenzo
-
p. 11206 - 11215
(2021/08/24)
-
- Rh(I)/(III)-N-Heterocyclic Carbene Complexes: Effect of Steric Confinement Upon Immobilization on Regio- and Stereoselectivity in the Hydrosilylation of Alkynes
-
Rh(I) NHC and Rh(III) Cp* NHC complexes (Cp=pentamethylcyclopentadienyl, NHC=N-heterocyclic carbene=pyrid-2-ylimidazol-2-ylidene (Py?Im), thiophen-2-ylimidazol-2-ylidene) are presented. Selected catalysts were selectively immobilized inside the mesopores
- Atwi, Boshra,Bauer, Matthias,Buchmeiser, Michael R.,Frey, Wolfgang,Nowakowski, Michal,Panyam, Pradeep K. R.,Ziegler, Felix
-
supporting information
p. 17220 - 17229
(2021/11/10)
-
- Additive-modulated switchable reaction pathway in the addition of alkynes with organosilanes catalyzed by supported Pd nanoparticles: Hydrosilylation: versus semihydrogenation
-
We herein report supported Pd nanoparticles on N,O-doped hierarchical porous carbon as a single operation catalyst-enabled additive-modulated reaction pathway for alkynes addition with organosilanes between hydrosilyation and semihydrogenation. In the case of alkynes hydrosilylation, a simple iodide ion as an additive has a promotion effect on the activity and regio- and stereoselectivity, where iodide can coordinate with Pd NPs via strong δ donation to increase the electron density of the Pd atom, resulting in an increased ability for the oxidative addition of hydrosilane as the rate-determining step to make the reaction proceed efficiently to afford vinylsilanes in high yields with excellent regio- and stereoselectivity. For the catalytic transfer semihydrogenation of alkynes, water was introduced to mix with organosilane to form a silanol together with the generation of hydrogen atoms on the Pd NPs surface or the liberation of H2 gas as a reducing agent, whereby the quantitative reduction of alkynes was achieved with exclusive selectivity to alkenes. In both cases, the catalyst could be recycled several times without a significant loss in activity or selectivity. A broad range of alkyl and aryl alkynes with various functional groups are compatible with the reaction conditions. The role the additive exerted in each reaction was extensively investigated through control experiments as well as the kinetic isotopic effect along with spectroscopic characterization. In addition, the respective mechanism operating in both reactions was proposed.
- Duan, Yanan,Ji, Guijie,Zhang, Shaochun,Chen, Xiufang,Yang, Yong
-
p. 1039 - 1050
(2018/03/05)
-
- Immobilization of Pyrene-Adorned N-Heterocyclic Carbene Complexes of Rhodium(I) on Reduced Graphene Oxide and Study of their Catalytic Activity
-
Two pyrene-tagged N-heterocyclic carbene (NHC) complexes of rhodium(I) were obtained and characterized. The two complexes were supported onto reduced graphene oxide (rGO), generating two new materials in which the molecular complexes are immobilized by π–
- Ruiz-Botella, Sheila,Peris, Eduardo
-
p. 1874 - 1881
(2017/12/07)
-
- Phosphoramidite complexes of Pd(II), Pt(II) and Rh(I): An effective hydrosilylation catalyst of 1-hexyne and 1-octene
-
The hydrophosphorane HP(OC6H4NMe)2 was used to prepare the diastereotopic complexes [MCl2{P(OC6H4NMe)OC6H4NHMe}] (M?=?Pd, Pt) by reaction with [MCl2(PhCN)2], and [RhCl(PPh3){P(OC6H4NMe)OC6H4NHMe}] by reaction with [RhCl(PPh3)3]. To form these complexes, the phosphorane undergoes ring-opening, whereby it is coordinated as the tautomeric neutral phosphoramidite-amino chelating ligand. The crystal structure of [RhCl(PPh3){P(OC6H4NMe)OC6H4NHMe}] was determined and the geometry about the Rh(I) atom is square-planar with cis-disposed phosphorus-donor ligands. The Rh–P distance is shortened (2.1056(6) ?) due to Rh(d)?→?P π-backbonding. In addition, [RhCl(PPh3){P(OC6H4NMe)OC6H4NHMe}] was shown to be an effective regio- and stereoselective catalyst for the hydrosilylation of 1-octene and 1-hexyne.
- Carroll, Hannah K.,Parlane, Fraser G.L.,Reich, Noah,Jelier, Benson J.,Montgomery, Craig D.
-
-
- Hydrosilylation of Terminal Alkynes Catalyzed by a ONO-Pincer Iridium(III) Hydride Compound: Mechanistic Insights into the Hydrosilylation and Dehydrogenative Silylation Catalysis
-
The catalytic activity in the hydrosilylation of terminal alkynes by the unsaturated hydrido iridium(III) compound [IrH(κ3-hqca)(coe)] (1), which contains the rigid asymmetrical dianionic ONO pincer ligand 8-oxidoquinoline-2-carboxylate, has been studied. A range of aliphatic and aromatic 1-alkynes has been efficiently reduced using various hydrosilanes. Hydrosilylation of the linear 1-alkynes hex-1-yne and oct-1-yne gives a good selectivity toward the β-(Z)-vinylsilane product, while for the bulkier t-Bu-C≡CH a reverse selectivity toward the β-(E)-vinylsilane and significant amounts of alkene, from a competitive dehydrogenative silylation, has been observed. Compound 1, unreactive toward silanes, reacts with a range of terminal alkynes RC≡CH, affording the unsaturated η1-alkenyl complexes [Ir(κ3-hqca)(E-CH=CHR)(coe)] in good yield. These species are able to coordinate monodentate neutral ligands such as PPh3 and pyridine, or CO in a reversible way, to yield octahedral derivatives. Further mechanistic aspects of the hydrosilylation process have been studied by DFT calculations. The catalytic cycle passes through Ir(III) species with an iridacyclopropene (η2-vinylsilane) complex as the key intermediate. It has been found that this species may lead both to the dehydrogenative silylation products, via a β-elimination process, and to a hydrosilylation cycle. The β-elimination path has a higher activation energy than hydrosilylation. On the other hand, the selectivity to the vinylsilane hydrosilylation products can be accounted for by the different activation energies involved in the attack of a silane molecule at two different faces of the iridacyclopropene ring to give η1-vinylsilane complexes with either an E or Z configuration. Finally, proton transfer from a η2-silane to a η1-vinylsilane ligand results in the formation of the corresponding β-(Z)- and β-(E)-vinylsilane isomers, respectively.
- Pérez-Torrente, Jesús J.,Nguyen, Duc Hanh,Jiménez, M. Victoria,Modrego, F. Javier,Puerta-Oteo, Raquel,Gómez-Bautista, Daniel,Iglesias, Manuel,Oro, Luis A.
-
p. 2410 - 2422
(2016/08/02)
-
- An alternative mechanistic paradigm for the β-Z hydrosilylation of terminal alkynes: The role of acetone as a silane shuttle
-
The β-Z selectivity in the hydrosilylation of terminal alkynes has been hitherto explained by introduction of isomerisation steps in classical mechanisms. DFT calculations and experimental observations on the system [M(I)2{κ-C,C,O,O-(bis-NHC)}]BF4 (M=Ir (3 a), Rh (3 b); bis-NHC=methylenebis(N-2-methoxyethyl)imidazole-2-ylidene) support a new mechanism, alternative to classical postulations, based on an outer-sphere model. Heterolytic splitting of the silane molecule by the metal centre and acetone (solvent) affords a metal hydride and the oxocarbenium ion [R 3Si - O(CH3)2]+, which reacts with the corresponding alkyne in solution to give the silylation product [R 3Si - CHi£C - R]+. Thus, acetone acts as a silane shuttle by transferring the silyl moiety from the silane to the alkyne. Finally, nucleophilic attack of the hydrido ligand over [R3Si - CHi£C - R]+ affords selectively the β-(Z)- vinylsilane. The β-Z selectivity is explained on the grounds of the steric interaction between the silyl moiety and the ligand system resulting from the geometry of the approach that leads to β-(E)-vinylsilanes. Silanes catch the shuttle: An outer-sphere mechanism that explains the β-Z hydrosilylation of terminal alkynes based on the role of acetone as a silane shuttle is disclosed. Heterolytic splitting of the silane molecule by the metal centre and acetone affords a metal hydride and the oxocarbenium ion [R 3Si - O(CH3)2]+, which reacts with the alkyne in solution to give the silylation product [R3Si - CHi£C - R]+ (see figure).
- Iglesias, Manuel,Sanz Miguel, Pablo J.,Polo, Victor,Fernandez-Alvarez, Francisco J.,Perez-Torrente, Jesus J.,Oro, Luis A.
-
p. 17559 - 17566
(2014/01/06)
-
- Exceptionally E- and β-selective NHC-Cu-catalyzed proto-silyl additions to terminal alkynes and site- and enantioselective proto-boryl additions to the resulting vinylsilanes: Synthesis of enantiomerically enriched vicinal and geminal borosilanes
-
An exceptionally site- and E-selective catalytic method for preparation of Si-containing alkenes through protosilylation of terminal alkynes is presented. Furthermore, the vinylsilanes obtained are used as substrates to generate vicinal or geminal borosilanes by another catalytic process; such products are derived from enantioselective protoborations of the Si-substituted alkenes. All transformations are catalyzed by N-heterocyclic carbene (NHC) copper complexes. Specifically, a commercially available imidazolinium salt, cheap CuCl (1.0 mol %) and Me2PhSi-B(pin), readily and inexpensively prepared in one vessel, are used to convert terminal alkynes to (E)-β-vinylsilanes efficiently (79-98 % yield) and in >98 % E and >98 % β-selectivity. Vinylsilanes are converted to borosilanes with 5.0 mol % of a chiral NHC-Cu complex in 33-94 % yield and up to 98.5:1.5 enantiomeric ratio (e.r.). Alkyl-substituted substrates afford vicinal borosilanes exclusively; aryl- and heteroaryl-substituted alkenes deliver the geminal isomers preferentially. Different classes of chiral NHCs give rise to high enantioselectivities in the two sets of transformations: C1-symmetric monodentate Cu complexes are most suitable for reactions of alkyl-containing vinylsilanes and bidentate sulfonate-bridged variants furnish the highest e.r. for substrates with an aryl substituent. Working models that account for the observed trends in selectivity are provided. Utility is demonstrated through application towards a formal enantioselective total synthesis of naturally occurring antibacterial agent bruguierol A. Different NHCs for different tasks: Three classes of N-heterocyclic carbene(NHC)-Cu complexes serve to promote two sets of reactions. Catalysts with an achiral monodentate NHC convert terminal alkynes to (E)-β-vinylsilanes with exceptional selectivity through efficient protosilylation. Cu-based catalysts bearing a chiral monodentate NHC bring about protoborations of alkyl-substituted vinylsilanes, generating enantiomerically enriched vicinal borosilanes; however, it is the sulfonate-bridged bidentate NHC-Cu complexes that deliver geminal silylborons with the highest e.r. values. Copyright
- Meng, Fanke,Jang, Hwanjong,Hoveyda, Amir H.
-
supporting information
p. 3204 - 3214
(2013/03/28)
-
- A synthon for a 14-electron Ir(iii) species: Catalyst for highly selective β-(Z) hydrosilylation of terminal alkynes
-
A synthon for a 14-electron Ir(iii) species is described. The geometrical control exerted by the ligand system over the Ir-alkenyl intermediate in hydrosilylation of terminal alkynes precludes formation of the more thermodynamically stable β-(E)-vinylsila
- Iglesias, Manuel,Perez-Nicolas, Maria,Miguel, Pablo J. Sanz,Polo, Victor,Fernandez-Alvarez, Francisco J.,Perez-Torrente, Jesus J.,Oro, Luis A.
-
supporting information
p. 9480 - 9482
(2012/10/29)
-
- N-heterocyclic carbene-amide rhodium(I) complexes: Structures, dynamics, and catalysis
-
The amide-functionalized imidazolium salts [BocNHCH2CH 2ImR]X (R = Me, X = I, 1a; R = benzyl, X = Br, 1b; R = trityl, X = Cl, 1c) bearing increasingly bulky N-alkyl substituents were prepared in high yields by direct alkylation of the (2-imidazol-1-yl-ethyl)carbamic acid tert-butyl ester; 1c is a crystalline solid also characterized by X-ray diffraction. These salts are precursors for the synthesis of rhodium(I) complexes [Rh(NBD)X(NHC)] (NHC = 1-(2-NHBoc-ethyl)-3-R-imidazolin-2-ylidene; X = Cl, R = Me (3a), R = benzyl (3b), R = trityl (3c); X = I, R = Me (4a)). All the complexes display restricted rotation about the metal-carbene bond; however, while the rotation barriers calculated for 3a,b and 4a matched the experimental values, unexpectedly this was not true in the case of 3c, where the experimental value was equal to that obtained for compound 3b (58.6 kJ mol-1) and much smaller with respect to the calculated one (100.0 kJ mol-1). The catalytic activity of the neutral rhodium(I) complexes 3a-c in the hydrosilylation of terminal alkynes with HSiMe2Ph has been investigated with PhC≡CH, TolC≡CH, nBuC≡CH, Et 3SiC≡CH, and (CPh2OH)C≡CH as substrates. The steric hindrance on the N-heterocyclic ligand and on the alkyne substrates affects conversion and selectivity: for the former the best results were achieved employing the less encumbered 3a catalyst with TolC≡CH, whereas by employing hindered alkynes such as Et3SiC≡CH or (CPh 2OH)C≡CH the hydrosilylation leads only to the formation of the β-(E)-vinylsilane and α-bis(silyl)alkene isomers. The complexes 3a,b have also been employed in the addition of arylaldehydes with phenylboronic acid, and like in the hydrosylylation case, the best results were obtained using 3a in the presence of aldehydes bearing electron-withdrawing groups, such as 4-cyanobenzaldehyde and 4-acetylbenzaldehyde as substrates.
- Busetto, Luigi,Cassani, M. Cristina,Femoni, Cristina,Mancinelli, Michele,Mazzanti, Andrea,Mazzoni, Rita,Solinas, Gavino
-
experimental part
p. 5258 - 5272
(2011/12/02)
-
- A simple route to chelating, structurally different triazole-based bis(N-heterocyclic carbene) ligands and their coordination to PtII
-
Two new bis(triazolium) salts have been prepared and used as N-heterocyclic carbene (NHC) precursors. The structure of the salts is highly dependent on the synthetic route, which implies the sequential alkylation of two of the three N atoms at the triazol
- Zanardi, Alessandro,Mata, Jose A.,Peris, Eduardo
-
scheme or table
p. 416 - 421
(2011/05/07)
-
- Silylzincation of carbon-carbon multiple bonds revisited
-
The first investigation of the copper-catalyzed silylzincation of alkynes as well as a diene and styrene using bis(triorganosilyl) zinc reagents led to the development of an efficient procedure and the disclosure of an unexpected bissilylation and unfores
- Auer, Gertrud,Oestreich, Martin
-
p. 311 - 313
(2008/02/08)
-
- Synthesis, reactivity, crystal structures and catalytic activity of new chelating bisimidazolium-carbene complexes of Rh
-
A series of new bridging, chelating and pincer N-heterocyclic carbenes of RhI and RhIII have been obtained under mild conditions. The compounds have been fully characterised and their crystal structures determined. The chelate-pincer
- Poyatos, Macarena,Mas-Marza, Elena,Mata, Jose A.,Sanau, Mercedes,Peris, Eduardo
-
p. 1215 - 1221
(2007/10/03)
-
- Transition Metal Complexes of Troeger's Base and their Catalytic Activity for the Hydrosilylation of Alkynes
-
Rhodium(III) and iridium(III) complexes of Troeger's base (TB), of structural type TB*2MCl3 (M=Rh, Ir), were prepared by treatment of TB with MCl3.The rhodium complex readily catalyzed the hydrosilylation of alkynes with high regio- and stereoselectively observed in some cases.
- Goldberg, Yuri,Alper, Howard
-
p. 369 - 372
(2007/10/02)
-
- Organosilicon compound and process for producing organosilicon compound
-
An organosilicon compound having a Si--C--C--Si bond, a C=C--Si bond and/or a CH--CH--Si bond is prepared by reacting an olefin or a substituted olefin with a disilane in the presence of a platinum-containing catalyst. The resulting compound can be further treated with an alkyl lithium, an aryl lithium or a Grignard reagent.
- -
-
-
- SILYLCUPRATION OF ACETYLENES
-
Several organosilylcuprates have been prepared and their reactions with acetylenes examined.It has been shown that LiCu2 adds to acetylenes in only one manner, i.e. with cis addition and the Si(SiMe3)3 group in the least hindered cite as shown
- Chen, Hsiao-Ming,Oliver, John P.
-
p. 255 - 260
(2007/10/02)
-
- Observations on Various Silyl-Cuprate Reagents
-
The mixed silyl-cuprate reagent (6), made from 1 equiv. of methyl-lithium, 1 equiv. of phenyldimethylsilyl-lithium, and 1 equiv. of copper(I) cyanide, reacts with 3-methylcyclohexenone (7), with methyl cinnamate (9), with 1-vinylcyclohexyl acetate (11), a
- Fleming, Ian,Newton, Trevor W.
-
p. 1805 - 1808
(2007/10/02)
-
- INTAMOLECULAR CYCLIZATION MEDIATED BY SILYLMETALATION OF ACETYLENES WITH PhMe2SiMgMe/CuI AND RADICAL NATURE OF THE REAGENT
-
Whereas CuI catalyzed silylmagnesation of the tosylate of 5-hexyn-1-ol with the title reagent affords dimethylphenylsilylmethylenecyclopentane exclusively, the mesylate of 3-butyn-1-ol gives a mixture of unexpected silylcyclobutene and cyclopropylidene derivative.
- Okuda, Yasuhiro,Morizawa, Yoshitomi,Oshima, Koichiro,Nozaki, Hitosi
-
p. 2483 - 2486
(2007/10/02)
-
- The Silylcupration of Acetylenes: a Synthesis of Vinylsilanes
-
Bis(dimethylphenylsilyl)copper-lithium (1) reacts with hex-1-yne, propyne, acetylene itself, phenylacetylene, and hex-3-yne to give the products of syn addition of the dimethylphenylsilyl group and the copper.The resultant vinylcopper reagents react with a variety of electrophiles, such as the proton, iodine, acyl and alkyl halides, enones, and epoxides, to give vinylsilanes.With the terminal alkynes, the silyl group becomes attached with a high level of regioselectivity to the terminal carbon atom, with the result that the final products are 2,2-disubstituted vinylsilanes.
- Fleming, Ian,Newton, Trevor W.,Roessler, Felix
-
p. 2527 - 2532
(2007/10/02)
-
- Reaction of a Silyl-Copper Reagent with Acetylenes: a New Synthesis of Vinylsilanes
-
A silyl-cuprate reagent adds regioselectively to terminal acetylenes and the intermediate (3) reacts with electrophiles to give 2,2-disubstituted vinylsilanes.
- Fleming, Ian,Roessler, Felix
-
p. 276 - 277
(2007/10/02)
-