- Aminothioxanthone Derivatives
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The present invention refers to 350 to 400 nm range of zero increase/decrease high absorbance of photocurable composition in use can be transporting, a light in an ultraviolet range by the irradiation of electromagnetic waves of fluorescent greater efficiency high efficiency that is capable of emitting light, the aminosilane is fluorescent materials reliability thioxanthone derivative.
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Paragraph 0070 - 0072
(2016/10/17)
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- A convenient synthesis of 9H-thioxanthen-9-ones and their aza-analogues
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An efficient method for the preparation of 9H-thioxanthen-9-ones and their three aza-analogues has been developed. The reaction of (2-fluorophenyl)(2- halophenyl)methanones, derived from 1-bromo-2-fluorobenzenes and 2- halobenzaldehydes by an easy two-step sequence, with Na2S· 9H2O in DMF at 60 °C gives 9H-thioxanthen-9-ones. This procedure can be applied to the synthesis of 5H-[1]benzothiopyrano[2,3-b](or [2,3-c])pyridin-5-ones or 10H-[1]-benzothiopyrano[3,2-c]pyridin-10-ones starting from 2-, 3- or 4-chloropyridines, respectively.
- Kobayashi, Kazuhiro,Komatsu, Toshihide,Nakagawa, Kazuhiro,Hara, Erika,Yuba, Shohei
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p. 2577 - 2587
(2014/01/06)
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- Synthesis and screening of 3-substituted thioxanthen-9-one-10,10-dioxides
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This manuscript describes methods appropriate for the parallel synthesis of libraries based on the tricyclic thioxanthen-9-one-10,10-dioxide scaffold. The novel compounds were synthesized from previously reported 3-chlorothioxanthen-9-one-10,10-dioxide and commercially available 3-carboxylic acid thioxanthen-9-one-10,10-dioxide. The library members were screened for activity in a fluorescence polarization assay for inhibitors of BRCT domains of breast cancer gene 1 and in cell-based secreted alkaline phosphatase reported replicon system for activity against hepatitis C virus.
- Lory, Pedro M.J.,Estrella-Jimenez, Maria E.,Shashack, Matthew J.,Lokesh, Ganesh L.,Natarajan, Amarnath,Gilbertson, Scott R.
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p. 5940 - 5943
(2008/09/21)
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- AGENTS THAT INHIBIT FLAVIVIRUS REPLICATION AND USES THEREOF
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The present invention provides compounds with activity against a variety of flaviviruses, uses thereof, and methods for identifying such compounds.
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Page/Page column 74-75
(2008/06/13)
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- An expedient route to 3-chlorothioxanthen-9-one-10,10-dioxide and derivation by palladium-catalyzed coupling
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Chemistry has been developed that allows for the synthesis of a series of novel tricyclic thioxanthen-9-one-10,10-dioxides. A regioselective synthesis of the novel core substrate 3-chlorothioxanthen-9-one-10,10-dioxide was achieved in 85% yield over three steps without the need for chromatographic purification. Subsequent microwave-assisted coupling methodology afforded the desired novel 3-substituted tricyclic compounds in good to excellent yield. Georg Thieme Verlag Stuttgart.
- Lory, Pedro M. J.,Agarkov, Anton,Gilbertson, Scott R.
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p. 3045 - 3048
(2008/02/13)
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- Thioxanthenone antitumor agents
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Compounds having anti-tumour activity are disclosed having the formulawherein: (1) n is 2 or 3;R1 and R2 are independently lower-alkyl;Q is a residue chosen from the group consisting ofCH2NHR3, CH2N(R4)SO2R7, CH2NHCHO, CH=N-Ar,C(O)NR5R6, CH2N(R4)C(O)R7, CH2N(C2H5)CHO,CH2N(R4)P(O)(O-lower-alkyl)2, CH2N=CH-N(R9)(R10),CH2N(R4)C(O)CF3 and CH2N(R4)C(O)OR7;R3 is hydrogen or lower-alkyl;R4 is hydrogen, lower-alkyl or Ar;R5 is hydrogen, lower-alkyl or Ar;R6 is hydrogen or lower-alkyl;R7 is lower-alkyl, or Ar;R8 is hydroxy;Ar is phenyl or phenyl substituted with methyl, methoxy, hydroxy, halogen or nitro; andR9 and R10 are independently lower-alkyl; or(2) Q is a residue chosen from the group consisting of CH2N(R4)SO2R7, CH=N-Ar, C(O)NR5R6, CH2N(R4)C(O)R7, CH2N(R4)P(O)(O-lower-alkyl)2, CH2N(R4)C(O)CF3 and CH2N(R4)C(O)OR7; R8 is hydrogen, lower-alkyl, lower-alkoxy, or hydroxy; Ar is phenyl substituted by hydroxy; and n, R1, R2, R4, R5, R6, and R7 are as defined hereinabove in part (1) with the proviso that one or more of R4, R5, or R7 is Ar; or(3) Q is a residue chosen from the group consisting of CH2N=CH-N(R9)(R10) and CH2N(R4)C(O)CF3 ; R8 is hydrogen, lower-alkyl, lower-alkoxy, or hydroxy; and n, R1, R2, R4, R7, Ar, R9 and R10 are as defined hereinabove in part (1), or a pharmaceutically acceptable acid-addition salt or solvate thereof . Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed.
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- Lyophilized thioxanthenone antitumor agents
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Disclosed are reconstituted lyophilized formulations for the treatment of mammalian tumors comprising a thioxanthenone antitumor agent in combination with mannitol or sucrose as a stabilizer in a lactate buffer.
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- Thioxanthenone antitumor agents
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1-[[(Dialkylamino)alkyl]amino]-4-substituted-thioxanthen-9-ones are disclosed as antitumor agents. Compositions containing the thioxanthenones and methods of treating tumors and cancer in mammals with the thioxanthenones are also disclosed.
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