- Synthesis of 2-bromo-4,5-difluorobenzoic acid
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The synthesis of 2-bromo-4,5-difluorobenzoic acid was achieved from difluorophthalic anhydride by either using a Losen rearrangement or the Barton bromodecarboxylation reaction.
- Braish,Fox
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p. 3067 - 3074
(2007/10/02)
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- Process for the preparation of fluorinated benzoic acids
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In the process for the preparation of fluorinated benzoic acids of the formula I STR1 in which X and Y, for example, independently of one another denote chlorine or fluorine and X moreover denotes bromine, a fluorinated chloroacetophenone of the formula II STR2 in which Z denotes chlorine or hydrogen, is reacted with a hypohalite.
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- Intermediates for preparing 1,4-dihydro-4-oxo-quinoline-3-carboxylic acid esters
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Compounds of the formula: wherein Y is OR1, fluoro, chloro, methyl, R1, and R3 are independently selected from hydrogen and C1-C4 alkyl, R2 is C1-C4 alkyl and X is fluoro, chloro or bromo, with the proviso that when Y is OH, X cannot be bromo and with the proviso that X can be fluoro only if R2 is methyl.
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