Thieno[3,2-c]pyrazoles: A novel class of Aurora inhibitors with favorable antitumor activity
A novel series of 3-amino-1H-thieno[3,2-c]pyrazole derivatives demonstrating high potency in inhibiting Aurora kinases was developed. Here we describe the synthesis and a preliminary structure-activity relationship, which led to the discovery of a represe
Heterobicyclic pyrazole derivatives as kinase inhibitors
Bicyclo-pyrazoles of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in
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Page/Page column 15
(2008/06/13)
HETEROBICYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS
Bicyclo-pyrazoles of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in
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Page 60-61
(2010/02/06)
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