- Synthesis of trifluoromethyl moieties by late-stage copper (I) mediated nucleophilic fluorination
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The nucleophilic fluorination of bromodifluoromethyl derivatives mediated by the complex (PPh3)3CuF is described. Under the reaction conditions, different trifluoroacetates, trifluoroketones, trifluoroarenes and trifluoroacetamides were obtained in good yields.
- Bermejo Góme, Antonio,González, Miguel A. Cortés,Lübcke, Marvin,Johansson, Magnus J.,Schou, Magnus,Szabó, Kálmán J.
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- Method and device for purifying 1,4-bis (bromodifluoromethyl) benzene
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A method and a device for purifying 1,4-bis(bromodifluoromethyl)benzene are disclosed. In order to solve the problem of hard to purify and separate 1,4-bis(bromodifluoromethyl)benzene crude products, diphenylmethane that has a higher boiling point and does not interact with 1,4-bis(bromodifluoromethyl)benzene is mixed with the 1,4-bis(bromodifluoromethyl)benzene crude products for evaporation. Afterwards, the purity of the vaporized product is detected and only that reaching an expected purity is collected to obtain high-purity 1,4-bis(bromodifluoromethyl)benzene.
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Page/Page column 2
(2008/06/13)
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- Method for production of halogen-containing aromatic compound
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This invention relates to a method for the production of an aromatic compound (II) having a (CH2)nCX2Br group (wherein X represents a fluorine or chlorine atom and the X's may be same or different, and n is an integer in the range of 0 to 4) by the reaction of photo-bromination of an aromatic compound (I) having a (CH2)nCX2H group (wherein X and n are as defined above) with a brominating agent, wherein the photo-bromination reaction is carried out while removing hydrogen bromide generated in the reaction system and/or in an atmosphere of a low oxygen content, and a halogen-containing naphthalene compound represented by the following formula (1): wherein Y represents —CF2H, —CF2Br, or —CHO group, Z1and Z2independently represent a halogen atom, and p and q independently are an integer in the range of 0 to 3.
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- A New Synthesis of Octafluoroparacyclophane
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A new synthesis of 1,1,2,2,9,9,10,10-octafluoroparacyclophane (2) is reported.Easy preparation of gram quantities of 2 is accomplished by treatment of α,α'-dibromo-α,α,α',α'-tetrafluoroxylene with a complex low-valent form of Ti which is made by reduction of TiCl4 with equimolar quantities of LiAlH4 in THF.Use of high-dilution techniques is required for the reaction to be successful.The formation of 2 is believed to proceed via the reactive monomeric species α,α,α',α'-tetrafluoro-p-xylylene (4).
- Dolbier, William R.,Asghar, Mohammed Ali,Pan, He-Qi,Celewicz, Lech
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p. 1827 - 1830
(2007/10/02)
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- SYNTHESIS OF 1,1,2,2,9,9,10,10-OCTAFLUORO-PARA-CYCLOPHANE
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1,1,2,2,9,9,10,10-Octafluoro-para-cyclophane was obtained by the pyrolysis of α,α'-di-bromo-α,α,α',α'-tetrafluoro-p-xylene using argon as the diluent with further trapping of the pyrolysis products in boiling toluene.The pyrolysis zone was filled with a copper packing to bind bromine.An efficient scheme was also developed for the preparation of α,α'-dibromo-α,α,α',α'-tetrafluoro-p-xylene starting from p-xylene.
- Grechkina, E. V.,Sochilin, V. A.,Pebalk, A. V.,Kardash, I. E.
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p. 1663 - 1665
(2007/10/02)
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