Process for preparing isomerically pure prodrugs of proton pump inhibitors
Synthetic methods for preparing isomerically pure N-arylsulfonyl derivatives of proton pump inhibitors which include a substituted benzimidazole nucleus are shown by the synthetic schemes and experimental description.
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(2010/02/10)
PRODRUGS OF PROTON PUMP INHIBITORS
Prodrugs of proton pump inhibitors of Formulas 1 through 4, (I-IV), where the symbols are as defined in the specification, and the R group includes at least one acidic group or its pharmaceutically acceptable salt, have improved aqueous solubility and bioavailability.
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Page 196
(2010/02/06)
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