- Quinoline Acids
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This invention relates generally to quinoline-based modulators of Liver X receptors (LXRs) and related methods.
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Page/Page column 23
(2009/04/24)
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- Carboxylic acid based quinolines as liver X receptor modulators that have LXRβ receptor binding selectivity
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A series of potent and binding selective LXRβ agonists was developed using the previously reported non-selective LXR ligand WAY-254011 as a structural template. With the aid of molecular modeling, it was found that 2,3-diMe-Ph, 2,5-diMe-Ph, and naphthalene substituted quinoline acetic acids (such as quinoline 33, 37, and 38) showed selectivity for LXRβ over LXRα in binding assays.
- Hu, Baihua,Quinet, Elaine,Unwalla, Rayomand,Collini, Mike,Jetter, James,Dooley, Rebecca,Andraka, Diane,Nogle, Lisa,Savio, Dawn,Halpern, Anita,Goos-Nilsson, Annika,Wilhelmsson, Anna,Nambi, Ponnal,Wrobel, Jay
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- NEW REARRANGEMENTS OF ARYLHYDRAZONES IN POLYPHOSPHORIC ACID: FORMATION OF DIARYL THIOETHERS AND DIARYLAMINES
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When heated at 100 deg C with polyphosphoric acid, several dimethylphenylhydrazones of 4-mercaptoacetophenone, 9, and 4-aminodimethylacetophenones, 12, give 4-acetyl-4'-aminodiphenyl thioethers, 11, and 4-acetyl-4'-aminodiphenylamine derivatives, 16, together with products arising from other, known, paths.Mechanisms of formation of the products are discussed.
- Sannicolo, Franco
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p. 351 - 356
(2007/10/02)
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