- Glycine receptor antagonist pharmacophore
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Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia and surgery, as well as treating neurodegenerative diseases including Alzheimer''s disease, amyotrophic lateral sclerosis, Huntington''s disease and Down''s syndrome, treating or preventing the adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions and inducing anesthesia are disclosed by administering to an animal in need of such treatment a compound which has high binding to the glycine receptor.
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- Disperse dyes which are convertible into a thermo-migration fast form
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The dyes according to the invention consist of a chromophore and a radical which, on heating, forms an isocyanate or isothiocyanate group. The latter reacts with a suitable group in the environment. Dyeings of excellent thermomigration fastness are obtained. The disclosed dyes are of the formulae STR1 where F is the radical of an azo, anthraquinone or tricyanovinyl dye which is free of water-solubilizing groups, B and B' are each independently of the other a direct bond or a bridge member, selected from the group consisting of a straight-chain or branched alkylene group having 2 to 8 C atoms or one of the following groups STR2 where R is hydrogen or C1 -C6 alkyl, n is an integer from 1 to 8 and m is an integer from 2 to 4, Z is O or S, V is a group which at a temperature between 180° and 240° C. is eliminated as a radical HV, and V' is a direct bond which is cleaved at a temperature between 180° and 240° C. or is a group which at such temperature turns, by ring opening and cleavage of the bond V'-C, into a group V'H, with the provisos that in the azo dyes the diazo component is not aminobenzisothiazole and the coupling component is not N-(β-phenylureidoethyl)-1-naphthylamine when the diazo component is 2,4-dinitro-6-bromoaniline.
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