- Protective Agent for Retinal Neuronal Cell Comprising Indazole Derivative as Active Ingredient
-
As a result of intensive studies for the purpose of finding a new medicinal use of an indazole derivative, it was found that an indazole derivative inhibits glutamate-induced retinal neuronal cell death in rat fetal retinal neuronal cells, in other words, the indazole derivative acts directly on the retinal neuronal cells and exhibits an effect of protecting retinal neuronal cells. Accordingly, the indazole derivative is useful for the prevention or treatment of an eye disease associated with retinal neuronal cell damage or retinal damage.
- -
-
Page/Page column 10
(2009/01/23)
-
- PROTECTIVE AGENT FOR RETINAL NEURONAL CELL COMPRISING INDAZOLE DERIVATIVE AS ACTIVE INGREDIENT
-
As a result of intensive studies for the purpose of finding a new medicinal use of an indazole derivative, it was found that an indazole derivative inhibits glutamate-induced retinal neuronal cell death in rat fetal retinal neuronal cells, in other words, the indazole derivative acts directly on the retinal neuronal cells and exhibits an effect of protecting retinal neuronal cells. Accordingly, the indazole derivative is useful for the prevention or treatment of an eye disease associated with retinal neuronal cell damage or retinal damage.
- -
-
Page/Page column 15
(2010/11/29)
-
- NOVEL INDAZOLE DERIVATIVE
-
An object of the present invention is to create a novel indazole derivative useful as a drug and to find a novel pharmacological action of the derivative. The compound of the present invention is represented by the formula [I] and has an excellent Rho kinase inhibiting action. In the formula, a ring X is a benzene ring or a pyridine ring; R1 and R2 are H or alkyl; R3 and R4 are halogen, H, OH, alkoxy, alkenyloxy, alkynyloxy, cycloalkyloxy, cycloalkenyloxy, aryloxy, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, carboxy, hydrocarbonyl, alkylcarbonyl, etc.; and R5 is halogen atom, H, OH, alkoxy, aryloxy, alkyl or aryl. Each group can be substituted.
- -
-
Page/Page column 44
(2008/06/13)
-
- INDAZOLYL-(4)-OXYPROPANOLAMINE COMPOUNDS AND THERAPEUTIC COMPOSITIONS
-
New indazolyl-(4)-oxypropanolamine compounds of the formula STR1 wherein R 1 is hydrogen or lower alkyl; and R 2 is straight-chain or branched lower alkyl which can be substituted by lower alkylthio;AND THE PHARMACOLOGICALLY COMPATIBLE SALTS T
- -
-
-
- INDAZOLE COMPOUNDS
-
Indazole compounds of the formula STR1 wherein R 1 is hydrogen or lower alkyl,R' is hydrogen or acyl, e.g., alkanoyl, andR 2 is benzyl or a radical of the general formula STR2 in which X is a reactive residue and Y is hydroxyl or X and Y toget
- -
-
-