- Kinetic study of the reactions of methyl 2,4,6-trinitrophenyl carbonate with anilines
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The title reactions in water are subjected to a kinetic investigation. Under excess amine, pseudo-first-order rate coefficients (kobsd) are obtained. Plots of kobsd against aniline concentration are linear, with kN as the slope. The Bronsted-type plot (log kN vs anilinium pK a) is linear with slope 0.7, consistent with a concerted mechanism. By comparison of these reactions with others, it is concluded that anilines destabilize the tetrahedral intermediate relative to isobasic pyridines. The change of 2,4-dinitrophenoxide by 2,4,6-trinitrophenoxide as the leaving group of the carbonate destabilizes the tetrahedral intermediate and makes possible a change in mechanism. ARKAT-USA, Inc.
- Castro, Enrique A.,Aliaga, Margarita E.,Santos, Jose G.
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experimental part
p. 23 - 30
(2011/05/15)
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- Phenylglycinamide and pyridylglycinamide derivatives useful as anticoagulants
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The present invention provides novel phenylglycinamide derivatives of Formula (I) or (IV): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables W, W1, Y, Z, R7, R8, R9, and R11 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.
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Page/Page column 57
(2010/11/25)
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