trans-3,4-Dimethyl-4-(3-carboxamidophenyl)piperidines: A novel class of μ-Selective opioid antagonists
trans-3,4-Dimethyl-4-(3-carboxamidophenyl)piperidines constitute a novel class of μ opioid receptor antagonists. The CONH2 group was found to be an effective isostere of the phenolic OH moiety. Structure-activity relationships at the piperidine
Le Bourdonnec, Bertrand,Belanger, Serge,Cassel, Joel A.,Stabley, Gabriel J.,DeHaven, Robert N.,Dolle, Roland E.