Design and Synthesis of Peptidomimetic Protein Farnesyltransferase Inhibitors as Anti-Trypanosoma brucei Agents
On the basis of the structure of the CVIM tetrapeptide substrate of mammalian protein farnesyltransferase, a series of imidazole-containing peptidomimetics was designed and synthesized, and their inhibition activity against Trypanosoma brucei protein farn
Ohkanda, Junko,Buckner, Frederick S.,Lockman, Jeffrey W.,Yokoyama, Kohei,Carrico, Dora,Eastman, Richard,De Luca-Fradley, Kate,Davies, Wendy,Croft, Simon L.,Van Voorhis, Wesley C.,Gelb, Michael H.,Sebti, Sa?d M.,Hamilton, Andrew D.
p. 432 - 445
(2007/10/03)
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