- HCl-mediated transamidation of unactivated formamides using aromatic amines in aqueous media
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We report transamidation protocol to synthesize a range of secondary and tertiary amides from weakly nucleophilic aromatic and hetero-aryl amines with low reactive formamide derivatives, utilizing hydrochloric acid as catalyst. This current acid mediated strategy is beneficial because it eliminates the need for a metal catalyst, promoter or additives in the reaction, simplifies isolation and purification. Notably, this approach conventionally used to synthesize molecules on gram scales with excellent yields and a high tolerance for functional groups.
- Dhawan, Sanjeev,Girase, Pankaj Sanjay,Kumar, Vishal,Karpoormath, Rajshekhar
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p. 3729 - 3739
(2021/10/14)
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- The preparation method of the zola non-nepal (by machine translation)
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The invention discloses a method for preparing zola non-nepal, the states the zola non-nepal the chemical name is 4 - {4 - [( {4 - chloro - 3 - (trifluoromethyl) phenyl] amino} carbonyl) amino] phenoxy} - N - methylpyridine - 2 - carboxamide; the process of the invention has simple process, raw materials are easy, economic and environmental protection, help to realize industrialization, can promote the zola non-nepal drug of economic and technological development, and reduces the production cost, high yield, low environmental pollution, is suitable for mass production. (by machine translation)
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- Synthesis and antiproliferative activity of pyridinylcarbonylpyrimidines against melanoma cell line
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The synthesis of the series of pyrimidinylamines 1a-d and pyrimidinylureas 1e-u bearing a novel pyridinylcarbonylpyrimidine scaffold and their antiproliferative activities against A375 human melanoma cell line were described. Among them, three compounds 1
- Ahn, Hyemi,Lee, Jun A.,Kim, Hwan,Oh, Chang-Hyun,Lee, So Ha,Sim, Taebo,Hah, Jung-Mi,Kim, Dong Jin,Yoo, Kyung Ho
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scheme or table
p. 1209 - 1214
(2011/11/06)
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