- Benzodioxoles: Novel cannabinoid-1 receptor inverse agonists for the treatment of obesity
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The application of the evolutionary fragment-based de novo design tool TOPology Assigning System (TOPAS), starting from a known CB1R (CB-1 receptor) ligand, followed by further refinement principles, including pharmacophore compliance, chemical tractabili
- Alig, Leo,Alsenz, Jochem,Andjelkovic, Mirjana,Bendels, Stefanie,Bénardeau, Agnès,Bleicher, Konrad,Bourson, Anne,David-Pierson, Pascale,Guba, Wolfgang,Hildbrand, Stefan,Kube, Dagmar,Lübbers, Thomas,Mayweg, Alexander V.,Narquizian, Robert,Neidhart, Werner,Nettekoven, Matthias,Plancher, Jean-Marc,Rocha, Cynthia,Rogers-Evans, Mark,R?ver, Stephan,Schneider, Gisbert,Taylor, Sven,Waldmeier, Pius
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p. 2115 - 2127
(2008/12/22)
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- Stereospecifically substituted benzo[1,3]dioxolyl derivatives
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The present invention relates to compounds of formula (I) wherein R1 and R2 are as defined in the description and claims, and pharmaceutically acceptable salts thereof, for use as therapeutically active substances. The compounds are
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Page/Page column 11
(2010/11/25)
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- NOVEL BENZODIOXOLES
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The present invention relates to compound of formula (I) Wherein R1, R2, R3, R4, R5, R6, R7, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases, which are associated with the modulation of CB1 receptors.
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- Bis-imidazolyl-bisphenylmethane and salts thereof
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Bis-imidazolyl-bisphenylmethane derivatives and pharmaceutically acceptable non-toxic salts thereof are useful as antimycotics especially against dermatomycosis caused by Trichophyton and Microsporium species and also against yeast infections of the skin and internal organs.
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