Biological reagents and methods for determining the mechanism in the generation of β-amyloid peptide
Disclosed are biological reagents which comprise compounds that inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in determining the cellular mechanism involved in the generation of β-amyloid peptide.
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(2008/06/13)
Mono-Protected Diamines. Nα-tert-Butoxycarbonyl α,ω-Alkanediamine Hydrochlorides from Amino alcohols.
Nα-tert-Butoxycarbonyl α,ω-alkanediamine hydrochlorides 3a-e are prepared from the amino alcohols in yields of 66-87percent.Reaction of the free amine with di-tert-butyl dicarbonate gives the N-tert-Butoxycarbonylamino alcohol 1a-e.One-pot conversion to the azide 2a-e via the mesylate under phase-transfer conditions followed by hydrogenolysis in the presence of chloroform yields the title compounds.
Mattingly, Phillip G.
p. 366 - 368
(2007/10/02)
Novel copolymers and superoxide dismutase modified with said copolymers
Described are copolymers comprising the copolymer--constituting units characterized in the claims and having an average molecular weight of 400 to 20,000. Furthermore superoxide dismutase (SOD) derivatives are described which can be obtained by modification with the above copolymers and have a single chemical structure, retain most of the enzymatic activity of SOD and exhibit a much prolonged plasma half-life. Therefore, they are useful as medicinal chemicals.
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(2008/06/13)
Partially Protected Polyamines
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Hansen, J. B.,Nielsen, M. C.,Ehrbar, U.,Buchardt, O.
p. 404 - 405
(2007/10/02)
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