- Substituted diaryl amide compound as well as preparation method and application thereof
-
The invention provides a substituted diaryl amide compound as well as a preparation method and application thereof. The substituted diaryl amide compound or a pharmaceutically acceptable salt thereofis of a structure of a formula [1] (the formula is shown
- -
-
Paragraph 0205; 0216; 0217
(2019/04/04)
-
- Preparation method of 2-methyl-5-aminotrifluorotoluene
-
The invention provides a preparation method of 2-methyl-5-aminotrifluorotoluene. The method comprises the following steps: reducing 2-trifluoromethylbenzaldehyde, serving as a raw material, with sodium borohydride to obtain 2-trifluoromethyl benzyl alcohol; performing chlorination by sulfoxide chloride to obtain 2-trifluoromethyl benzyl chloride; nitrifying to obtain 2-chloromethyl-5-nitryltrifluorotoluene; lastly, performing hydrogenation reduction to obtain a target product, namely, 2-methyl-5-aminotrifluorotoluene. The method has the advantages of easiness in operation, high product yield, low cost and easiness in industrialization. The chemical formula of the 2-methyl-5-aminotrifluorotoluene is shown in the description.
- -
-
Paragraph 0051; 0058; 0064
(2017/06/24)
-
- HETEROBICYCLIC CARBOXAMIDES AS INHIBITORS FOR KINASES
-
The invention relates to novel compounds of formula (I) and their use in the treatment of the animal or human body, to pharmaceutical compositions comprising a compound of formula (I) and to the use of a compound of formula (I) for the preparation of pharmaceutical compositions for use in the treatment of protein kinase dependent diseases, especially of proliferative diseases, such as in particular tumour diseases.
- -
-
-
- Regioselective electrophilic trifluoromethylation of substituted anilines and derivatives in superacid
-
In a one pot procedure, treatment of chloro or methyl substituted acetanilides in HF/SbF5/CCl4 followed by addition of HF/pyridine yields trifluoromethyl derivatives with high regioselectivity.
- Debarge, Sébastien,Violeau, Bruno,Bendaoud, Nohair,Jouannetaud, Marie-Paule,Jacquesy, Jean-Claude
-
p. 1747 - 1750
(2007/10/03)
-