Discovery of thiophene inhibitors of polo-like kinase
The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented.
Emmitte, Kyle A.,Andrews, C. Webb,Badiang, Jennifer G.,Davis-Ward, Ronda G.,Dickson, Hamilton D.,Drewry, David H.,Emerson, Holly K.,Epperly, Andrea H.,Hassler, Daniel F.,Knick, Victoria B.,Kuntz, Kevin W.,Lansing, Timothy J.,Linn, James A.,Mook Jr., Robert A.,Nailor, Kristen E.,Salovich, James M.,Spehar, Glenn M.,Cheung, Mui
scheme or table
p. 1018 - 1021
(2009/09/06)
THIOPHENE COMPOUNDS
The present invention provides compounds of formula (I): (I) pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.
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Page 124-125
(2008/06/13)
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