Conversion of Secondary Furfuryl Alcohols and Isomaltol to Maltol and Related γ-Pyrones
A one-pot synthesis of maltol and ethylmaltol is reported.Treatment of methylfurfuryl alcohol with 2 equiv of halogen affords good yields of 4-halo-6-hydroxy-2-methyl-2H-pyran-3(6H)-ones (8), which need not be isolated and can be converted to maltol by aqueous hydrolysis in the same vessel.A similar sequence employing ethylfurfuryl alcohol yields ethylmaltol.By a related series of reactions, isomaltol (9) can be converted to maltol.
Weeks, Paul D.,Brennan, Thomas M.,Brannegan, Daniel P.,Kuhla, Donald E.,Elliot, Mark L.,et al.
p. 1109 - 1113
(2007/10/02)
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