Combination therapies for treatment of cancers associated with mutations in the KRAS gene are provided. Compositions comprising therapeutic agents for treatment of cancers associated with mutations in the KRAS gene are also provided.
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Paragraph 323
(2016/04/09)
COVALENT INHIBITORS OF KRAS G12C
Irreversible inhibitors of G12C mutant K-Ras protein are provided. Also disclosed are methods to modulate the activity of G12C mutant K-Ras protein and methods of treatment of disorders mediated by G12C mutant K-Ras protein.
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Paragraph 0461
(2014/09/30)
Reactions of Organic Anions, 147.- Simple and General Synthesis of Hydroxy- and Methoxyindoles via Vicarious Nucleophilic Substitution of Hydrogen
A simple synthesis of 4-, 5-, 6-, and 7-hydroxy- and -methoxyindoles via cyanoalkylation of O-protected nitrophenols by vicarious nucleophilic substitution of hydrogen, followed by catalytic hydrogenation of the (2-nitroaryl)acetonitriles obtained is described.
Makosza, Mieczyslaw,Danikiewicz, Witold,Wojciechowski, Krzysztof
p. 203 - 208
(2007/10/02)
Methoxylation of 3,4-dinitrochloro(bromo)benzene
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Varenikova, S. F.,Nekhoroshev, A. A.,Sevbo, D. P.
p. 1651 - 1652
(2007/10/02)
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