- Evaluation of the anticancer properties of the predicted hBaxBH3-mimetic compound 2-hydroxy-3,5-dinitrobenzamide in a mammary carcinogenesis-induced rat model
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Designing small molecular prototypes having potential to disrupt binding interfaces of pro-apoptotic-anti-apoptotic/BH3-only proteins is a promising strategy in cancer chemotherapy. Several natural and synthetic chemical compounds have been reported as in
- Sivakumar, Dakshinamurthy,Surapaneni, Krishna Mohan,Prabu, Ponnachipudhur Chinnaswamy,Hari, Natarajan,Thiruvasagam, Ponnusamy,Rajasekaran, Muthu,Sivaraman, Thirunavukkarasu
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p. 2854 - 2869
(2016/01/16)
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- Discovery of fluoroquinolone derivatives as potent, selective inhibitors of PI3Kγ
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Phosphoinositide 3-kinase (PI3K) is an attractive target to potentially treat a range of disease states as illustrated by more than 15 inhibitors now in clinical trials. We disclose herein the discovery of a new class of fluoroquinolone derivatives having
- Sha, Shao,Han, Hong-Wei,Gao, Fei,Liu, Tian-Bao,Li, Zhen,Xu, Chi,Zhong, Wei-Qing,Zhu, Hai-Liang
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supporting information
p. 2029 - 2035
(2015/11/17)
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- Urea thiadiazole inhibitors of plasminogen activator inhibior-1
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Methods of treating disorders associated with elevated levels of PAI-1 are disclosed comprising administering to a patient in need thereof a therapeutically effective amount of at least one compound of formula (I), or a pharmaceutically-acceptable salt, prodrug, stereoisomer or solvate thereof, wherein: A is aryl o heteroaryl, and R1-R12, are defined herein. The invention also pertains to pharmaceutical compositions and compounds within the scope of formula (I) as well as medicaments and articles of manufacture comprising compounds of formula (I).
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Page/Page column 34
(2010/02/11)
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- Modulators of cysteine protease
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The present invention concerns novel mediators of the activity of picornavirus 3C protease and the modulation of the activity of other similar proteins. The modulators may be used in pharmaceutical compositions either for inhibition of 3C protease (for example in viral infections) or for the enhancement of the activity of proteins similar to the 3C protease such as Apopain (for induction of apoptosis).
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Page/Page column 15-16
(2008/06/13)
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- Synthesis and Biological Activities of 1,1′-Bis(p-substituted-benzoyloxy-substituted-phenyl)cyclohexane
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1,1′-Bis(p-substituted-benzoyloxy-substituted-phenyl)cyclohexane have been synthesized. Most of the compounds exhibit promising antibacterial activity and moderate anifungal activity.
- Rajkotia,Parsania
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p. 524 - 525
(2007/10/03)
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