Optimization of physicochemical properties for 4-anilinoquinazoline inhibitors of trypanosome proliferation
Human African trypanosomiasis (HAT) is a deadly disease in need of new chemotherapeutics that can cross into the central nervous system. We previously reported the discovery of 2 (NEU-617), a small molecule with activity against T. brucei bloodstream prol
Woodring, Jennifer L.,Bachovchin, Kelly A.,Brady, Kimberly G.,Gallerstein, Mitchell F.,Erath, Jessey,Tanghe, Scott,Leed, Susan E.,Rodriguez, Ana,Mensa-Wilmot, Kojo,Sciotti, Richard J.,Pollastri, Michael P.
p. 446 - 459
(2017/10/24)
1,4-DISUBSTITUTED ISOQUINILONE DERIVATIVES AS RAF-KINASE INHIBITORS USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES
This invention relates to compounds of formula (I) wherein the variable substituents are described herein. The compounds are useful for the treatment of conditions and diseases characterized by an aberrant MAP kinase signaling pathway, such as cancer.
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Page/Page column 50-51
(2010/02/11)
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