- Mechanism of ceftriaxone degradation in aqueous solution
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Degradation of ceftriaxone in aqueous solutions was studied at 310 K and 353 K in acidic, basic and neutral conditions. In the next stage of hydrolysis there was observed: hydrolysis of the group -CH2-S- at C-3, opening of β-lactam ring, isomerization (epimerization at C-6 or C-7, izomerization syn-anti of N-oxime function) and lactonization of 4-carboxyl and CH2OH group. This study indicated on the instability of the -CH2-S- group at C-3 in the acidic, basic and neutral solutions.
- Zajac, Marianna,Muszalska, Izabela
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- Determination of cephalosporins and decomposition products by liquid chromatography with indirect electrochemical detection
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Indirect electrochemical detection, using in-line electrochemically generated bromine as oxidizing agent, has been used for the determination of cephalosporins with liquid chromatography. The method presents a general detection principle for cephalosporins since it is related to their basic structure. The detection limits obtained, which were between 0. 4 and 3 ng, and the repeatability with a relative standard deviation below 1. 5% comply with the requirements for drug stability studies in vitro.
- Fabre,Kok
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p. 136 - 141
(2007/10/02)
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