- Activation of iodosobenzene by catalytic tetrabutylammonium iodide and its application in the oxidation of some isoquinoline alkaloids
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Oxidation of N-methyltetrahydroisoquinolines with iodosylbenzene in the presence of a catalytic amount of tetrabutylammonium iodide in various solvents afforded N-methyl-2H-3,4-dihydroisoquinol-1-ones in almost quantitative yields. The application of this finding to the oxidation of other isoquinolines, including tetrahydroisoquinolines, lycorine diacetate, and benzyltetrahydroisoquinolines, also afforded the corresponding lactams in good yields, however, accompanied by a few minor byproducts. Under similar conditions, tetrahydroberberine gave a rearranged compound, berberal, as the major product, accompanied by 8-oxoberberine and berberine.
- Huang, Wei-Jan,Singh, Om V.,Chen, Chung-Hsiung,Chiou, Sheng-You,Lee, Shoei-Sheng
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p. 1069 - 1078
(2007/10/03)
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- Berberis ALKALOIDS. XVI. STRUCTURE OF BERPODINE
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The alkaloid composition of young shoots of Berberis heteropoda has been studied.Together with known alkaloids, we have isolated the new dimeric base berpodine and have established its structure by a study of spectral characteristics and by chemical transformations.The known alkaloid isotetrandrine has also been isolated from this plant, for the first time.
- Karimov, A.,Abdullaev, N. D.,Shakirov, R.
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p. 219 - 221
(2007/10/02)
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