- A [2]rotaxane capped by a cyclodextrin and a guest: Formation of supramolecular [2]rotaxane polymer
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A [2]rotaxane capped by a β-cyclodextrin and a 2,4,6-trinitrophenyl group has been prepared by dissolving 6-aminocinnamoyl β-cyclodextrin in water with 1-adamantane carboxylic acid and complexation with α-cyclodextrin followed by the reaction with 2,4,6-trinitrobenzene sulfonic acid sodium salt. The [2]rotaxane has been found to form supramolecular polymers by host-guest interactions. Copyright
- Miyauchi, Masahiko,Hoshino, Taiki,Yamaguchi, Hiroyasu,Kamitori, Shigehiro,Harada, Akira
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- Synthesis of 2-(N-cyclicamino)quinoline combined with methyl (E)-3-(2/3/4-aminophenyl)acrylates as potential antiparasitic agents
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A rationally designed series of 2-(N-cyclicamino)quinolines coupled with methyl (E)-3-(2/3/4-aminophenyl)acrylates was synthesized and subjected to in vitro screening bioassays for potential antiplasmodial and antitrypanosomal activities against a chloroquine-sensitive (3D7) strain of Plasmodium falciparum and nagana Trypanosoma brucei brucei 427, respectively. Substituent effects on activity were evaluated; meta-acrylate 24 and the ortho-acrylate 29 exhibited the highest antiplasmodial (IC50 = 1.4 μM) and antitrypanosomal (IC50 = 10.4 μM) activities, respectively. The activity against HeLa cells showed that the synthesized analogs are not cytotoxic at the maximum tested concentration. The ADME (absorption, distribution, metabolism, and excretion) drug-like properties of the synthesized compounds were predicted through the SwissADME software.
- Bokosi, Fostino R. B.,Beteck, Richard M.,Laming, Dustin,Hoppe, Heinrich C.,Tshiwawa, Tendamudzimu,Khanye, Setshaba D.
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- On the azo dyes derived from benzoic and cinnamic acids used as photosensitizers in dye-sensitized solar cells
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In order to get a better insight into the relationship between molecular structure and photovoltaic performance, six monoazo dye molecules containing benzoic and cinnamic acid moieties were synthesized and their photovoltaic properties were studied. Three of them have not been previously used in solar cells. Spectroscopic measurements of the investigated compounds coupled with theoretical calculations were performed. Short-circuit current density, open-circuit voltage, and fill-factor were determined. It was found that a larger amount of short-circuit current density will be generated if the HOMO–LUMO energy gap is lower, determined by the stability of the molecule and the electronic effect of the donor moiety. Among both series of synthesized dye molecules, the highest obtained values of short-circuit current density were achieved with (2-hydroxynaphthalene-1-ylazo)benzoic acid and (2-hydroxynaphthalene-1-ylazo)cinnamic acid, and thus they were regarded as promising candidates for application in dye-sensitized solar cells.
- Matovi?, Luka,Tasi?, Nikola,Tri?ovi?, Nemanja,La?arevi?, Jelena,Vitnik, Vesna,Vitnik, ?eljko,Grgur, Branimir,Mijin, Du?an
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p. 1183 - 1203
(2019/09/10)
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- Pd–Schiff base complex supported on Fe3O4 magnetic nanoparticles: A new and highly efficient reusable catalyst for C–C bond formation in water
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A protocol is introduced for the preparation of a new cage-like Pd–Schiff base organometallic complex supported on Fe3O4 nanoparticles (Fe3O4@Schiff-base-Pd). The structure of the nanomagnetic catalyst was comprehensively characterized using Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy, Brunauer–Emmett–Teller measurements, scanning electron microscopy (SEM), transmission electron microscopy, X-ray mapping, thermogravimetric analysis, vibrating sample magnetometry and inductively coupled plasma atomic emission spectroscopy. In the second stage, the catalytic activity of this catalyst was studied in the Suzuki and Heck cross-coupling reactions in water as a green solvent. In this sense, simple preparation of the catalyst from commercially available materials, high catalytic activity, simple operation, short reaction times, high yields and use of green solvent are some advantages of this protocol. Finally, the nanocatalyst was easily recovered, using an external magnet, and reused several times without significant loss of its catalytic efficiency. In addition, the stability of the catalyst after recycling was confirmed using SEM, XRD and FT-IR techniques.
- Lei, Lei
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- Synthesis and Catalytic Applications of [N,N]-Pyrrole Ligands for the Regioselective Synthesis of Styrene Derivatives
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We report the synthesis of two [N,N]-donor ligands (5 a–b) containing a 2-chalcogenazoline as the structural motif. These compounds were synthesized from a common intermediate Fischer type aminocarbene complex (3). The palladium-complexes of these [N,N]-donor ligands were successfully used as catalytic precursors in the Mizoroki-Heck coupling reaction between aryl halides and methyl acrylate, styrene and ethylene. For methyl acrylates, high yields with TOF values between 0.6 and 5.5×105 h?1 were obtained. In the case of ethylene, we reached high regioselectivities to obtain a diversity of styrene derivatives under soft pressure conditions, with good values of TON and TOF. (Figure presented.).
- Hochberger-Roa, Frank,Cortés-Mendoza, Salvador,Gallardo-Rosas, David,Toscano, Ruben A.,Ortega-Alfaro, M. Carmen,López-Cortés, José G.
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supporting information
p. 4055 - 4064
(2019/07/31)
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- Fe3O4@Boehmite-NH2-CoII NPs: An inexpensive and highly efficient heterogeneous magnetic nanocatalyst for the Suzuki-Miyaura and Heck-Mizoroki cross-coupling reactions
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Herein we report the synthesis of a magnetically separable core-shell-like Fe3O4@Boehmite-NH2-CoII NPs as an environmentally friendly heterogeneous catalyst. The as-prepared nanocatalyst was well characterized by various techniques such as FT-IR, XRD, BET, TEM, FE-SEM, EDX, TGA, H2-TPR, VSM, ICP-OES and elemental analysis and evaluated for the Suzuki-Miyaura and Heck-Mizoroki cross-coupling reactions in a green solvent (H2O). The results of characterization studies revealed the superparamagnetic behavior of the Fe3O4 NP core encapsulated by a Boehmite NP shell. Also, it was clearly found that the size of the particles was about 13-54 nm. In comparison with previously reported catalysts, Fe3O4@Boehmite-NH2-CoII NPs exhibited perfect catalytic efficiency for the Suzuki-Miyaura and Heck-Mizoroki cross-coupling reactions under mild conditions without using toxic solvents. The concerted effects between individual components of the catalyst and also its unique egg-like nanostructure led to the high catalytic performance of Fe3O4@Boehmite-NH2-CoII NPs. Also, the introduction of Co significantly lowers the cost of the catalyst. More importantly, the longevity of the nanocatalyst was studied and it was found that the magnetic nanocatalyst was stable under the reaction conditions and could be easily reused for at least seven consecutive cycles without a discernible decrease in its catalytic activity or metal leaching.
- Mohammadinezhad, Arezou,Akhlaghinia, Batool
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p. 5625 - 5641
(2017/12/06)
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- Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat
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Concomitant inhibition of multiple oncogenic pathways is a desirable goal in cancer therapy. To achieve such an outcome with a single molecule would simplify treatment regimes. Herein the core features of ruxolitinib (1), a marketed JAK1/2 inhibitor, have been merged with the HDAC inhibitor vorinostat (2), leading to new molecules that are bispecific targeted JAK/HDAC inhibitors. A preferred pyrazole substituted pyrrolopyrimidine, 24, inhibits JAK1 and HDACs 1, 2, 3, 6, and 10 with IC50 values of less than 20 nM, is 100 nM potent against JAK2 and HDAC11, and is selective for the JAK family against a panel of 97 kinases. Broad cellular antiproliferative potency of 24 is supported by demonstration of JAK-STAT and HDAC pathway blockade in hematological cell lines. Methyl analogue 45 has an even more selective profile. This study provides new leads for assessment of JAK and HDAC pathway dual inhibiton achieved with a single molecule.
- Yao, Lianbin,Mustafa, Nurulhuda,Tan, Eng Chong,Poulsen, Anders,Singh, Prachi,Duong-Thi, Minh-Dao,Lee, Jeannie X. T.,Ramanujulu, Pondy Murugappan,Chng, Wee Joo,Yen, Jeffrey J. Y.,Ohlson, Sten,Dymock, Brian W.
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p. 8336 - 8357
(2017/11/03)
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- Pd0.09Ce0.91O2-Δ: A sustainable ionic solid-solution precatalyst for heterogeneous, ligand free Heck coupling reactions
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A quick and easy method for the preparation of Pd2+ metal ion substituted in ceria, Pd0.09Ce0.91O2-δ solid solution oxide, is described. The Pd0.09Ce0.91O2-δ solid solution oxide was fully characterized by XRD, ICP-OES, BET, XPS, SEM, EDX, TEM, TGA and Raman spectroscopy. All characterization techniques strongly suggested that Pd2+ was successfully incorporated into the lattice structure of ceria. The effect of the reaction conditions on the catalytic properties of the Pd0.09Ce0.91O2-δ solid solution catalyst initially was studied in detail with the model Heck reaction of iodobenzene and methylacrylate to obtain optimum reaction conditions. The Pd0.09Ce0.91O2-δ solid solution catalyst then afforded substituted alkenes in good to excellent yields under these optimum reaction conditions. Steric and electronic effects were also studied, and were found to influence the catalytic activity. Characterization of the used catalyst suggests that Pd2+ in Pd0.09Ce0.91O2-δ is reduced in situ to Pd0 when employed in the Heck cross-coupling reactions. The catalyst was easily recovered by centrifuge and reused three times without significant loss of catalytic efficiency.
- Mpungose, Philani P.,Sehloko, Neo I.,Dasireddy, Venkata D.B.C.,Mahadevaiah, Narayanappa,Maguire, Glenn E.,Friedrich, Holger B.
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- Arylhydrazones Derivatives Containing a Benzothiazole Moiety, Efficient Ligands in the Palladium-Catalyzed Mizoroki–Heck and Suzuki–Miyaura Cross-coupling Reactions under IR Irradiation
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A simple arylhydrazone containing the benzothiazole moiety which may be used as an efficient ligand in the palladium-catalyzed Mizoroki–Heck and Suzuki–Miyaura cross-coupling reactions, under infrared irradiation as an alternative source of energy, is presented. The reactions proceeded with extremely high efficiency under mild conditions and produced very good yields.
- Ortega-Jiménez, Fernando,Penieres-Carrillo, José Guillermo,López-Cortés, José Guadalupe,Carmen Ortega-Alfaro,Lagunas-Rivera, Selene
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p. 1881 - 1888
(2017/09/12)
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- Synthesis and evaluation of substituted 4-(N-benzylamino)cinnamate esters as potential anti-cancer agents and HIV-1 integrase inhibitors
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Encouraging selectivity and low micromolar activity against HeLa cervical carcinoma (IC50? 3.0 μM) and the aggressive MDA-MB-231 triple negative breast carcinoma (IC50? 9.6 μM) cell lines has been exhibited by a number of readily acc
- Faridoon,Edkins, Adrienne L.,Isaacs, Michelle,Mnkandhla, Dumisani,Hoppe, Heinrich C.,Kaye, Perry T.
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p. 3810 - 3812
(2016/07/21)
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- Infrared irradiation or microwave assisted cross-coupling reactions using sulfur-containing ferrocenyl-palladacycles
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The synthesis of four new sulfur-containing palladacycles 3a-d [FcC(S)OEtPdClZR3, where: 3a, ZR3: PPh3; 3b, ZR3: P(o-Tol)3; 3c, ZR3: PMe3; 3d, ZR3: SbPh3] from ferrocenyl thionoester 1 [FcC(S)OEt] in good yields is reported. The catalytic applications of these cyclopalladated complexes in Heck and Suzuki cross-coupling reactions were also evaluated, in combination with infrared or microwave as energy sources. The coupled products of these reactions were obtained in good to excellent yields, short reaction times and low catalyst loading.
- Balam-Villarreal,Sandoval-Chávez,Ortega-Jiménez,Toscano,Carreón-Castro,López-Cortés,Ortega-Alfaro
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- Palladium-bis(oxazoline) complexes with inherent chirality: Synthesis, crystal structures and applications in Suzuki, Heck and Sonogashira coupling reactions
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New palladium-bis(oxazoline) (Pd-BOX) complexes were synthesized and characterized. The X-ray crystal structures of the two complexes showed that the palladium ion is bound to the nitrogen atoms of the two heterocycles of the bidentate ligand and two chloride ions in a distorted square planar geometry. The coordination to the palladium ion allows these non C2-symmetric bis(oxazoline) ligand-based complexes to acquire a rigid backbone curvature generating an inherent chirality. The catalytic activities were evaluated in Suzuki-Miyaura, Mizoroki-Heck and Sonogashira coupling reactions. The complexes showed high catalytic activities towards numerous C-C coupling reactions with various aryl halides, aryl boronic acids, alkenes and alkynes. The reactions were optimized for the most suitable temperature, solvent, and base system.
- Shakil Hussain,Ibrahim, Mansur B.,Fazal, Atif,Suleiman, Rami,Fettouhi, Mohammed,El Ali, Bassam
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- Synthesis of [N,P] ligands based on pyrrole. Application to the total synthesis of arnottin i
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This paper describes the synthesis of a new class of [N,P] ligands based on pyrrole with a dimethylamino group as hard donor and a phosphine moiety as soft base. We have also modified the phosphine fragment to change the electronic and steric properties of these ligands. Palladium complex 3a proved to be very efficient in Heck cross-coupling reactions and in intramolecular aryl-aryl couplings of esters and amides. We have demonstrated the applicability and efficiency of this novel catalyst in the total synthesis of the natural product arnottin I.
- Suárez-Meneses, Jesús V.,Bonilla-Reyes, Edgar,Blé-González, Ever A.,Ortega-Alfaro, M. Carmen,Toscano, Rubén Alfredo,Cordero-Vargas, Alejandro,López-Cortés, José G.
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supporting information
p. 1422 - 1430
(2014/02/14)
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- In situ stabilization of Pd0-nanoparticles into the nanopores of modified Montmorillonite: Efficient heterogeneous catalysts for Heck and Sonogashira coupling reactions
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In situ generation of Pd0-nanoparticles into the nanopores of modified Montmorillonite and their catalytic performance in carboncarbon bond formation namely Heck and Sonogashira reactions, have been carried out. The modification of Montmorillonite was carried out by activating with H 2SO4 under controlled conditions for generating nanopores on the surface, which act as a 'Host' for Pd0-nanoparticles and was prepared by loading of K2PdCl4 metal precursor through incipient wetness impregnation technique followed by reduction with hydrazine hydrate. Powder-XRD, SEM-EDX, TEM, N2 adsorption, XPS, etc. analyses were carried out to characterize the stabilized nanoparticles as well as the supports. TEM study reveals that Pd0-nanoparticles of size below 10 nm were evenly distributed on the support and exhibit face centered cubic (fcc) lattice. The supported metal nanoparticles serve as efficient heterogeneous catalyst for the Heck coupling reaction in which the vinylation of aryl halides with olefins result cross-coupling products with maximum 96% isolated yield and >99% trans selectivity while in the alkynylation of aryl halides with terminal alkynes, i.e. in Sonogashira coupling reaction, a maximum of 94% isolated yield with 100% selectively cross-coupling products were observed. The nanocatalysts could be recycled and reused several times without significant loss of their catalytic activities.
- Borah, Bibek Jyoti,Dutta, Dipak Kumar
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p. 202 - 209
(2013/02/22)
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- Structure-based design of a new series of d-glutamic acid based inhibitors of bacterial UDP-N-acetylmuramoyl-l-alanine: D-glutamate ligase (MurD)
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MurD ligase is one of the key enzymes participating in the intracellular steps of peptidoglycan biosynthesis and constitutes a viable target in the search for novel antibacterial drugs to combat bacterial drug-resistance. We have designed, synthesized, and evaluated a new series of d-glutamic acid-based Escherichia coli MurD inhibitors incorporating the 5-benzylidenethiazolidin-4- one scaffold. The crystal structure of 16 in the MurD active site has provided a good starting point for the design of structurally optimized inhibitors 73-75 endowed with improved MurD inhibitory potency (IC50 between 3 and 7 μM). Inhibitors 74 and 75 showed weak activity against Gram-positive Staphylococcus aureus and Enterococcus faecalis. Compounds 73-75, with IC 50 values in the low micromolar range, represent the most potent d-Glu-based MurD inhibitors reported to date.
- Toma?i?, Tihomir,Zidar, Nace,?ink, Roman,Kova?, Andreja,Blanot, Didier,Contreras-Martel, Carlos,Dessen, Andréa,Müller-Premru, Manica,Zega, Anamarija,Gobec, Stanislav,Kikelj, Danijel,Peterlin Ma?i?, Lucija
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p. 4600 - 4610
(2011/09/14)
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- Ce0.98Pd0.02O2-δ: Recyclable, ligand free palladium(II) catalyst for Heck reaction
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Palladium substituted in cerium dioxide in the form of a solid solution, Ce0.98Pd0.02O1.98 is a new heterogeneous catalyst which exhibits high activity and 100% trans-selectivity for the Heck reactions of aryl bromides including heteroaryls with olefins. The catalytic reactions work without any ligand. Nanocrystalline Ce0.98Pd 0.02O1.98 is prepared by solution combustion method and Pd is in +2 state. The catalyst can be separated, recovered and reused without significant loss in activity. Indian Academy of Sciences.
- Sanjaykumar,Mukri, Bhaskar Devu,Patil, Satish,Madras, Giridhar,Hegde
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experimental part
p. 47 - 54
(2012/02/05)
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- BICYCLIC HETEROCYCLES HYDROXAMATE COMPOUNDS USEFUL AS HISTONE DEACETYLASE (HDAC) INHIBITORS
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The present invention relates to hydroxamate compounds which are inhibitors of histone deacetylase. More particularly, the present invention relates to heterocyclic containing compounds and methods for their preparation. These compounds may be useful as medicaments for the treatment of proliferative disorders as well as other diseases involving, relating to or associated with enzymes having histone deacetylase (HDAC) activities.
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- Selective reduction of nitrocinnamoylfumagillols with α,β- unsaturated ester using Borohydride Exchange Resin (BER) - nickel acetate
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Borohydride Exchange Resin (BER) - nickel acetate system readily reduces nitrocinnamoylfumagillols to the corresponding amines in excellent yields, high chemoselectivity, and simple procedure. Especially, this system tolerates two epoxides (spiro-epoxide
- Hong, Woo Lee,Joong, Bok Ahn,Jung, Hwa Lee,Sung, Kwon Kang,Soon, Kil Ahn,Sang, Joon Lee
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p. 1843 - 1856
(2007/10/03)
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- Novel sulfonamide derivatives as inhibitors of histone deacetylase
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Inhibition of the enzyme histone deacetylase (HDAC) is emerging as a novel approach to the treatment of cancer. A series of novel sulfonamide derivatives were synthesized and evaluated for their ability to inhibit human HDAC. Compounds were identified which are potent enzyme inhibitors, with IC 50 values in the low nanomolar range against enzyme obtained from HeLa cell extracts, and with antiproliferative effects in cell culture. Extensive characterization of the structure - activity relationships of this series identified key requirements for activity. These include the direction of the sulfonamide bond and substitution patterns on the central phenyl ring. The alkyl spacer between the aromatic head group and the sulfonamide functionality also influenced the HDAC inhibitory activity. One of these compounds, m11.1, also designated PXD101, has entered clinical trials for solid tumors and haematological malignancies.
- Finn, Paul W.,Bandara, Morwena,Butcher, Chris,Finn, Angela,Hollinshead, Ruth,Khan, Nagma,Law, Norman,Murthy, Sreenivasa,Romero, Rosario,Watkins, Clare,Andrianov, Victor,Bokaldere, Rasma M.,Dikovska, Klara,Gailite, Vija,Loza, Einars,Piskunova, Irina,Starchenkov, Igor,Vorona, Maxim,Kalvinsh, Ivars
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p. 1630 - 1657
(2007/10/03)
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- Carbamic acid compounds comprising a sulfonamide linkage as hdac inhibitors
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This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the following formula: (I) A is an aryl group; Q1 is a covalent bond or an aryl leader group; J is a sulfonamide linkage selected from: —S (═O)2NR1— and —NR1S(═O)2—; R1 is a sulfonamido substituent; and, Q2 is an acid leader group; with the proviso that if J is —S(═O)2NR1—, then Q1 is an aryl leader group; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and, e.g., to inhibit proliferative conditions, such as cancer and psoriasis.
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- Carbamic acid compounds comprising an amide linkage as hdac inhibitors
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This invention pertains to certain active carbamic acid compounds which inhibit HDAC activity and which have the formula (1) wherein: A is an aryl group; Q1 is an aryl leader group having a backbone of at least 2 carbon atoms; J is an amide linkage selected from: —NR1C(═O)—and —C(═O)NR1—; R1 is an amido substituent; and, Q2 is an acid leader group; and pharmaceutically acceptable salts, solvates, amides, esters, ethers, chemically protected forms, and prodrugs thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit HDAC, and, e.g., to inhibit proliferative conditions, such as cancer and psoriasis.
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- Zn2+-Chelating Motif-Tethered Short-Chain Fatty Acids as a Novel Class of Histone Deacetylase Inhibitors
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Among various classes of histone deacetylase (HDAC) inhibitors, short-chain fatty acids exhibit the least potency, with IC50 in the millimolar range. We rationalized that this weak potency was, in part, attributable to their inability to access the zinc cation in the HDAC active-site pocket, which is pivotal to the deacetylation catalysis. We thus explored the structural optimization of valproate, butyrate, phenylacetate, and phenylbutyrate by coupling them with Zn2+-chelating motifs (hydroxamic acid and o-phenylenediamine) through aromatic ω-amino acid linkers. This strategy has led to a novel class of Zn2+-chelating, motif-tethered, short-chain fatty acids that exhibited varying degrees of HDAC inhibitory potency. One hydroxamatetethered phenylbutyrate compound, N-hydroxy-4-(4-phenylbutyrylamino)benzamide (HTPB), displayed nanomolar potency in inhibiting HDAC activity. Exposure of several cancer cell lines to HTPB at the submicromolar level showed reduced cell proliferation accompanied by histone hyperacetylation and elevated p21WAF/CIP1 expression, which are hallmark features associated with intracellular HDAC inhibition.
- Lu, Qiang,Yang, Ya-Ting,Chen, Chang-Shi,Davis, Melanie,Byrd, John C.,Etherton, Mark R.,Umar, Asad,Chen, Ching-Shih
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p. 467 - 474
(2007/10/03)
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- Hydrazinium monoformate: A new hydrogen donor. Selective reduction of nitrocompounds catalyzed by commercial zinc dust
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The nitro group in aliphatic and aromatic nitro compounds also containing reducible substituents such as ethene, nitrile, acid, phenol, halogen, ester, etc., are selectively and rapidly reduced at room temperature to corresponding amines in good yields by employing hydrazinium monoformate, in the presence of commercial zinc dust. It was observed that, hydrazinium monoformate is more effective than hydrazine or formic acid and reduction of nitro group occurs without hydrogenolysis in the low cost zinc dust compared to expensive metals like palladium.
- Gowda, Shankare,Gowda, B. K. Kempe,Gowda, D. Channe
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p. 281 - 289
(2007/10/03)
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- Use of a new hydrophilic phosphine: DPPPA. Rapid and convenient Heck reaction in aqueous medium under microwave irradiation
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A new water soluble phosphine-ligand: diphenylphosphinyl) phenylphosphonic acid (DPPPA) was used in Heck reaction. The Heck reaction is efficiently and rapidly achieved by a palladium-catalysed reaction in water performed in a Teflon autoclave under microwave irradiation with a commercial microwave oven. The Log P was used for correlating the solubility of the aryl iodide in water with the observed yield.
- Villemin,Nechab
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p. 429 - 431
(2007/10/03)
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- Preparation and pharmacological evaluation of novel glycoprotein (Gp) IIb/IIIa antagonists. 2. Condensed heterocyclic derivatives
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A novel series of platelet receptor glycoprotein (Gp) IIb/IIIa antagonists with condensed heterocycles as their basic core was synthesized. In an in vitro assay, trans-4-(5-amidinobenzofuran-2- carboxamido)cyclohexyl]oxyacetic acid 17e and trans-3-[4-(5-
- Ono, Shin'ichiro,Yoshida, Tomohiro,Maeda, Kazuhiro,Kosaka, Keigo,Inoue, Yoshihisa,Imada, Teruaki,Fukaya, Chikara,Nakamura, Norifumi
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p. 1694 - 1712
(2007/10/03)
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- Molecular analytical release tags and their use in chemical analysis
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A release tag reagent suitable for use in the chemical analysis of a substance to be detected, which substance contains reactive groups, such as for, but not limited to gas phase detection groups, which reagent comprises three covalently bonded groups: a
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