- Preparation method of fluorine-containing carboxylic acid
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The invention discloses a preparation method of fluorine-containing carboxylic acid. The method comprises the following steps: reacting fluorine-containing carboxylate used as a raw material with an acylating chlorination reagent to obtain a corresponding mixture of fluorine-containing acyl chloride and fluorine-containing anhydride, and hydrolyzing and drying the mixture of fluorine-containing acyl chloride and fluorine-containing anhydride to obtain high-purity fluorine-containing carboxylic acid. The method provided by the invention is suitable for post-treatment of fluorine-containing carboxylic acid prepared by a fluorine-containing olefin (monoolefine, diene, cycloolefin and the like) oxidation method, replaces the traditional strong acid acidification and ether continuous extractionprocess, and is simpler, more convenient and more applicable; and the method can also be used for recovering and purifying a fluorine-containing carboxylate emulsifier. The purity of the fluorine-containing carboxylic acid prepared by the method can reach 98% or above.
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Paragraph 0031
(2020/07/12)
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- Preparation method of fluorine-containing dicarboxylic acid
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The invention discloses a preparation method of fluorine-containing dicarboxylic acid, which comprises: by using fluorine-containing cycloolefin as a raw material, performing oxidation with an oxidantunder the actions of a solvent and a catalyst to generate the corresponding fluorine-containing dicarboxylic acid. According to the method, a mixed solvent composed of the organic solvent and water is used as a solvent system of an oxidation reaction, the fluorine-containing cycloolefin is oxidized into corresponding fluorine-containing dicarboxylic acid by using the oxidant under the action of the catalyst, and the method has the characteristics of simple operation, stable process, safety, short reaction time, high yield and high product quality, and is suitable for large-scale production.
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Paragraph 0045-0047
(2020/07/12)
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- Practical preparation of 3,3-difluoropyrrolidine
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A practical and cost-effective synthesis of 3,3-difluoropyrrolidine is reported. The synthesis involves the isolation of two intermediates, which are prepared via two efficient through processes: (1) a Claisen rearrangement followed by a Ru(VIII)-catalyzed oxidation to prepare the 2,2-difluorosuccinic acid and (2) an efficient cyclization to form N-benzyl-3,3-difluoropyrrolidinone followed by BH3·Me2S reduction.
- Xu, Feng,Simmons, Bryon,Armstrong III, Joseph,Murry, Jerry
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p. 6105 - 6107
(2007/10/03)
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