- Synthesis method of cefamoxef sodium
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The invention relates to a synthesis method of latamoxef sodium. The synthesis method specifically comprises the following steps: reacting an oxygen cephalosporin mother nucleus 1 with 1-methyl-5-mercaptotetrazole sodium salt to obtain a compound 2, carrying out deprotection to obtain a compound 3, adding methoxyl and a 7-site side chain on the compound 3 to obtain a compound 5, and then, carryingout final deprotection on the compound 5 to obtain high-purity latamoxef sodium. The method provided by the invention is high in yield, mild in condition and environment-friendly; enzyme is used fordeprotection and condensation reaction, so that high-toxicity and high-corrosivity reagents are avoided; and the high-purity latamoxef sodium is obtained at a high yield.
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- METHOD FOR MANUFACTURING 7alpha-ALKOXYOXACEPHEM INTERMEDIATE COMPOUND
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The present disclosure provides a method for preparing a 7α-alkoxyoxacephem intermediate compound, the method comprising a process (S1) including: reacting a compound represented by a following chemical formula 1 with a halogen compound in an organic solv
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- 7 β-amino -7 α-methoxy-3-cephem compound preparation method
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The invention relates to a preparation method of a medical raw material 7beta-amino-7lapha-methoxy-3-cephem compound. Methods in prior arts have the problems of more steps and low yield. According to the 7beta-amino-7lapha-methoxy-3-cephem compound preparation method provided by the invention, a beta-lactam compound is adopted as a raw material, and is subjected to a reaction with bis(trichloromethyl)carbonate under the existence of an organic alkali, such that a iminochloride-beta-lactam compound is produced; methanol is added for alcoholysis, such that the 7beta-amino-7lapha-methoxy-3-cephem compound is produced. The method provided by the invention has the advantages of mild and easy-to-control reaction conditions, high yield, no product of 7alpha-methoxy-7beta-amino-3-cephem compound isomer, and easy separation. With the method, the 7beta-amino-7lapha-methoxy-3-cephem compound product with ultrahigh purity can be obtained.
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Paragraph 0045; 0046
(2017/03/17)
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- PROCESS FOR THE PREPARATION OF (1-OXA- OR l-THIA-)3- CEPHEM DERIVATIVES AND RELATED INTERMEDIATES
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There is described a process for the preparation of carboxy-protected 7β-amino-7α-methoxy-(l-oxa- or l-thia-)3-(l-substituted-lH-tetrazol-5-yl)thiomethyl-3- cephem-4-carboxylic acid. Said process comprises (a) reacting a carboxy- protected 7-amino-3-chlor
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Page/Page column 13-14; 16
(2010/11/28)
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- Stereochemistry in borohydride reduction of 7-imino-cephems: An improved method for conversion of the 7α-amino- 1-oxa(thia)cephems into the 7β-amino isomers
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Sodium cyanoborohydride in methanol containing hydrogen chloride (pH ~3) proved to be an excellent reagent system for smooth and highly stereo-selective reduction of the 7-imino-1-oxa(thia)cephems 6 or their equivalent 7-methoxy amines 8 to the correspond
- Aoki, Tsutomu,Nagata, Wataru
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p. 687 - 695
(2007/10/02)
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- STEREOCONTROLLED, STRAIGHTFORWARD SYNTHESIS OF 3-SUBSTITUTED METHYL 7α-METHOXY-1-OXACEPHEMS
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Stereocontrolled and industrially feasible synthesis of a new antibiotic 1a and related derivates, which is characterized by using all the carbon atoms of the penicillin skeleton, is described.
- Yoshioka, Mitsuru,Tsui, Teruji,Uyeo, Shoichiro,Yamamoto, Sadao,Aoki, Tsutomu,at al.
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p. 351 - 354
(2007/10/02)
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