cas 66611-51-6, 2-(NAPHTH-1-YL)ACETAMIDE OXIME | Articles data ｜lookchem

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66611-51-6

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Synthesis of 4,5-dihydro 1,2,4-oxadiazoles from N-unsubstituted amidoximes
4,5-Dihydro 1,2,4-oxadiazoles can be synthesized from aromatic and araliphatic amidoximes by cyclocondensation with aldehydes and ketones. Resulting heterocycles differ in substitution at C-3 and C-5 showing the scope of the simple reaction.
Lessel,Herfs
p. 22 - 26
(2007/10/03)

Discovery of potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70
A series of 1,2,4-oxadiazole analogues has been shown to be potent and selective SH2 inhibitors of the tyrosine kinase ZAP-70, a potential therapeutic target for immune suppression. These compounds typically are 200- 400-fold more potent than the native,
Vu, Chi B.,Corpuz, Evelyn G.,Merry, Taylor J.,Pradeepan, Selvaluxmi G.,Bartlett, Catherine,Bohacek, Regine S.,Botfield, Martyn C.,Eyermann, Charles J.,Lynch, Berkley A.,MacNeil, Ian A.,Ram, Mary K.,Van Schravendijk, Marie Rose,Violette, Shelia,Sawyer, Tomi K.
p. 4088 - 4098
(2007/10/03)

More Articles about upstream products of 66611-51-6

132-75-2
naphthalen-1-ylacetonitrile

Chemical Properties

Melting Point: 127 °C
Boiling Point: 439.9 °C at 760 mmHg
Flash Point:219.8oC
Density: 1.19 g/cm³
PSA: 58.61000
LogP: 2.82900

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