Fimctlonalized tetrazoles from cyanogen azide with secondary amines
Secondary amines react with cyanogen azide at ambient temperature in water/acetonitrile to provide tetrazole derivatives directly. The scope and limitations with regard to steric hindrance of the amine are discussed. Although reaction yields are moderate, 29-81%, the cyanogen azide reactions provide a direct and versatile route to functionalized tetrazoles that: may be especially useful considering the diversity of amines suitable for this transformation.
Joo, Young-Hyuk,Shreeve, Jean'ne M.
experimental part
p. 3573 - 3578
(2009/10/26)
A general route to 5-aminotetrazoles
Various di- and trisubstituted (benzotriazolyl)- carboximidamides were used for the preparation of N,N-di-and 1,N,N-trisubstituted 5-aminotetrazoles 3a-e and 6a-d under mild conditions in good to excellent yields.
Katritzky, Alan R.,Rogovoy, Boris V.,Kovalenko, Katherine V.
p. 4941 - 4943
(2007/10/03)
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